Posted by Larry Hoover on August 21, 2007, at 16:30:48
In reply to Re: SSRIs and bone loss » Larry Hoover, posted by Quintal on August 21, 2007, at 15:36:21
> So what is the vitamin D link Lar?
Standard therapy for low bone density. It alters the balance between osteoblast and osteoclast activities. Bone is constantly being dissolved (osteoclast) and recrystallized (osteoblast), with bone density being the dynamic equilibrium between the opposing actions. Maybe SSRIs do inhibit the blasts....but vitamin D activates them.
> I see this older study found increased risk of hip fracture in all groups taking antidepressants, but the SSRI group had the highest incidence. Interesting, because I get the impression the researchers seem to have set out expecting to find a lower incidence of hip fracture among SSRI users because they are 'better tolerated' (I assume they were thinking sedation and cognitive impairment was the cause of falls, and hence higher incidence of hip fractures, but their results seem to suggest a different mechanism).
I'd have speculated on the orthostatic hypotension and heart rhythm disturbances associated with tricyclics....On reading the abstract, I don't see anything about mechanism.
Lar
poster:Larry Hoover
thread:777598
URL: http://www.dr-bob.org/babble/20070815/msgs/777614.html