Posted by sdb on December 23, 2006, at 17:04:05
In reply to Re: pindolol, does it increase the risk of diabeti » sdb, posted by Quintal on December 23, 2006, at 16:13:19
Hi Quintal,
You are welcome. Thanks for your help and your input. I think you're absolutely right that some betablockers should be carefully used for people with diabetes risk such as positive family anamnesis, pathological glucose tolerance and steroid medication. You know, in Great Britain it is discussed to avoid betablockers in first line treatment in essential hypertension. There are many new meds for hypertension available such as ACE-inhibitors, AT1-antagonists, vasodilators...
But a definitive fact is that betablockers are still widely and effectively used since many years for hypertension but many other cardiovascular disorders too.>If you're doing meta-analysis there are other >studies bring more clarity what is meant with >"increase risk for diabetes".
>>Then please provide them
Of course I would like to do but there are tons of studies so I can't give a clear picture here.
But back to the topic I can't predict the clinical effect without data for an individual of a combination parnate and pindolol. I would like to refer at the subject-title.
Kind regards
sdb
> >Almost every betablocker has a similar molecular structure but not all. And even if the structure is similar the effects are different and vary. Betablockers have different actions concerning endocrinology.
>
> I imagine so. I also presume you have evidence - studies of some kind to prove each beta blocker has different actions concerning endocrinology? We can't leave anything to chance afterall, or heaven forbid, be seen to make a generalization.
>
> >Furthermore the study seems to be pretty old.
>
> That study seems to have been conducted in 2000 - old by research standards maybe, but still relevant considering the length of time beta-blockers have been in use. I imagine the drugs have similar effects on human beings regardless of when the study was conducted.
>
> >If you're doing meta-analysis there are other studies bring more clarity what is meant with "increase risk for diabetes".
>
> Then please provide them. I posted what I thought was likely to be one of the studies that the person writing the wikipedia article used as his/her sources. I'd never heard of beta-blockers causing diabetes before and I wrote to that effect in my post before deciding to do a quick Google and check. When I found evidence to the contrary I was forced to re-write my original message. That study was the first I found and it seemed like a good idea to post it for medievil's perusal because this is afterall a public message board designed for mutual support not a peer reviewed research committee.
>
> I happen to be in the final stages of roasting my turkey. Had I not been rushing backwards and forwards to grease it I would have spent more time examining the evidence. If those are the standards that are expected of me around here then I'll make a note to be more careful in future.
>
> Kind regards
>
> Q
poster:sdb
thread:715894
URL: http://www.dr-bob.org/babble/20061217/msgs/716009.html