Posted by sdb on December 23, 2006, at 15:31:15
In reply to Re: pindolol, does it increase the risk of diabeti » sdb, posted by Quintal on December 23, 2006, at 14:42:26
"Beta-blockers may increase risk for diabetes."
Almost every betablocker has a similar molecular structure but not all. And even if the structure is similar the effects are different and vary. Betablockers have different actions concerning endocrinology. Which one may increase? - imprecise. Furthermore the study seems to be pretty old. If you're doing meta-analysis there are other studies bring more clarity what is meant with "increase risk for diabetes".
kind regards
sdb
> I don't think pindolol would prevent a hypertensive crisis with Parnate but it may cause hypotension, or worse, potentate any hypotensive action of Parnate may have on you. Pindolol is a non-selective beta-blocker and may increase your risk of diabetes like other drugs of its class by causing hyperglycemia.
>
> --------------------------------------------------
> Beta-blockers Raise Diabetes Risk
>
> March 30, 2000 - Beta-blockers may increase risk for diabetes. Dr. Frederick Brancati studied data on 12,550 non-diabetic patients from 45 to 64 years of age. At 3 and 6 years, patients were screened for diabetes.
> Overall, patients with high blood pressure were 2-1/2 times more likely than others to develop type 2 diabetes. After adjusting for other factors, patients taking a thiazide diuretic, an ACE inhibitor, or calcium channel blocker did not have higher risk for diabetes. However, the risk for diabetes was 1-1/4 times higher for beta-blocker patients.
> The authors note that "this adverse effect must be weighed against the proven benefits of beta-blockers in reducing risk of cardiovascular events."
>
> Source: N Engl J Med 2000;342:905-912,969-970
> http://www.chfpatients.com/coreg.htm#beta-blockers_diabetes
> --------------------------------------------------
>
> Pindolol:
> "It acts on serotonin (5-HT1A) receptors in the brain resulting in increased postsynaptic serotonin concentrations."
> http://en.wikipedia.org/wiki/Pindolol
>
> Does this pose an increased risk of serotonin syndrome?
>
> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9507085&dopt=Abstract#
>
> According to that article the combination of fluoxetine and 5-HT1A antagonist 'is reported to enhance extracellular levels of serotonin greater than fluoxetine alone'. It doesn't cause serotonin syndrome with fluoxetine, so the same may be true with Parnate, but with MAOIs I'd like to tread carefully where serotonin is concerned - it could creep up on you suddenly as you increase the dose. Does your pdoc say it's safe?
>
> Q
poster:sdb
thread:715894
URL: http://www.dr-bob.org/babble/20061217/msgs/715980.html