Posted by psychobot5000 on December 20, 2006, at 17:46:46
In reply to Re: Tianeptine MOA » saturn, posted by blueberry1 on December 19, 2006, at 19:01:19
Re:"Tianeptine does not lower serotonin levels.
Tianeptine does have minor effects on norepinephrine and dopamine. But they aren't well researched, just known to exist. And it has other functions throughout the body on stress systems. And who knows what affinity it might have as say for example an agonist at 5HT1a receptors or whatever. I imagine it is probably a combination of all its mysterious actions that makes it what it is, and that the serotonin reuptake enhancement is just a trigger or just one link in the chain. "
____________________________According to what I've read, tianeptine does lower synaptic serotonin levels. For sure. It also raises platelet serotonin levels, and these two bits of information are apparently not at all contradictory. I have read multiple abstracts and articles that -say- it has been confirmed synaptic serotonin is lower. I have not read anything indicating that serotonin release was increased in response, however I suppose it might be possible.
Also, according to an academic article I've read, it has no effects on 5HT1 receptors. It does apparently have some mild MAO-A inhibition, but probably too low to have and AD effect. I can't vouch for any of this information--just repeating what I'v read.
One can do a google search or go to www.biopsychiatry.com to find study abstracts or academic articles--there are several out there examining its properties.
poster:psychobot5000
thread:714901
URL: http://www.dr-bob.org/babble/20061217/msgs/715267.html