Posted by linkadge on December 20, 2006, at 20:48:00
In reply to Re: Tianeptine MOA, posted by elanor roosevelt on December 20, 2006, at 20:18:10
Not all SSRI's are antidepressants. I remember reading about a few investiagational serotonin uptake inhibitors that displayed no antidepressant potential.
One study showed that the SSRIs we have increased the activity of an enzyme that produces allopregnanalone (sp.), a potent gabaergic neurosteroid by some 20x.
So, it might not be the serotonin that calming at all, but allopregnanalone.
Linkadge
poster:linkadge
thread:714901
URL: http://www.dr-bob.org/babble/20061217/msgs/715318.html