Posted by blueberry1 on December 19, 2006, at 19:01:19
In reply to Re: Tianeptine MOA, posted by saturn on December 19, 2006, at 17:46:11
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> So is tianeptine purported to work by ultimately lowering serotonin?
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> Or is there perhaps an alleged compensatory increase of serotonin production?
>
> Or other???No one really knows. It is my own theory that as serotonin is taken out of circulation faster, the brain makes up for it by firing/releasing more of it. Compared to ssris, I kind of look at it as a stagnant pool of serotonin versus a fast flowing stream of fresh serotonin. But, that's purely a guess and could be way wrong.
Tianeptine does not lower serotonin levels.
Tianeptine does have minor effects on norepinephrine and dopamine. But they aren't well researched, just known to exist. And it has other functions throughout the body on stress systems. And who knows what affinity it might have as say for example an agonist at 5HT1a receptors or whatever. I imagine it is probably a combination of all its mysterious actions that makes it what it is, and that the serotonin reuptake enhancement is just a trigger or just one link in the chain.
poster:blueberry1
thread:714901
URL: http://www.dr-bob.org/babble/20061217/msgs/715084.html