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Re: Tianeptine

Posted by djmmm on December 19, 2006, at 17:26:03

In reply to Re: Tianeptine » saturn, posted by psychobot5000 on December 19, 2006, at 14:58:50

> > >>>>... there isn't much money in studying it.
> >
> > Why is this? It's not an herb or naturally occuring substance, is it?
>
> No, it's not natural. Tianeptine isn't very profitable because (I don't understand why) it's not cleared for use--primarily in the US, but also in some European countries. Its risks seem low, but for whatever reason, its manufacturer, Servier, either hadn't the resources to spend hundreds of millions to get it approved in the US, or didn't realize what a good agent it was until it had too few years left on the patent, or thought the risks of it not getting approved were too high, for whatever reason. None of these make too much sense to me, really, but now its patent is too old for it to make financial sense to take it through the approval process...unless something actually comes from its (apparently separate) patent for development to treat IBS.
>
> It's too bad. Perhaps it was largely its relationship with amineptine that made people in the approval process wary of pursuing it. But as someone said, there is a lot of research on it--only not some of the more organized research and clinical reports on drug-interactions, side-effects and etc, as far as I can tell.
>

It's not available because it decreases serotonin--since all the major drug companies are pushing SSRIs, and the "serotonin" theory of depression. Tianeptine simply does not fit in with the current trend in treatment. Millions are spent in research, promoting a "serotonin deficiency" theory. Tianeptine effectivly disproves this, and ultimately brings into question the role of SSRIs in depression.


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URL: http://www.dr-bob.org/babble/20061217/msgs/715068.html