Posted by sdb on July 8, 2006, at 18:57:54
In reply to Re: Rumination-snapper (nm), posted by sdb on July 8, 2006, at 6:09:04
> > > > > From benzo.org.uk:
> > > > > also known as Lorazepam, the equivalence is
> > > > >
> > > > > 1-2Ativan : 0.5Klonopin
> > > >
> > > > > http://benzo.org.uk/ (Equivalence Table).
> > > > > Squiggles
> > > >
> > > > Nice equivalence table, bad table cell ;)
> > > >
> > > > Take a look again on the table and you'll see that 1 mg (NOT 1 - 2 mg) of Lorazepam (Ativan) is equivalent to 0.5 mg of Clonazepam (Klonopin).
> > > >
> > > > See ya around
> > > > Marty
> > > >
> > >
> > >
> > > If you want to change the duration of action and the amount (ng/ml) of clonazepam during time you can simply drink some grapefruit juice (clonazepam is mainly substrate of CYP3A4, grapefruit juice is an "OTC" inhibitor of CYP3A4). The effect of grapefruit juice
> > ....
> > > sdb
> >
> >
> > "duration" but not potency right?
> >
> > Squiggles
> >
>
> Yes.Here is a study but diazepam is not only metabolized by CYP3A4:
------------------------------------------------------------------Eur J Drug Metab Pharmacokinet. 1998 Jan-Mar;23(1):55-9. Related Articles, Links
Interaction between grapefruit juice and diazepam in humans.
Ozdemir M, Aktan Y, Boydag BS, Cingi MI, Musmul A.
Department of Pharmacology, Medical Faculty, University of Osmangazi, Eskisehir, Turkey.
Grapefruit juice has been reported to markedly improve the bioavailability of triazolam, midazolam, terfenadine, cyclosporine and several dihydropyridine calcium channel blockers including felodipine, nifedipine, nitrendipine and nisoldipine. Because these drugs are metabolized by the hepatic cytochrome P450 isozyme (CYP) 3A4, the inhibitory effect of grapefruit juice is thought to results from inhibition of CYP3A4. In this study, our aim was to investigate the effects of grapefruit juice on plasma concentrations of diazepam. Eight healthy male and female subjects participated in this study. Oral (5 mg) diazepam was administered with either 250 ml water and grapefruit juice. Blood samples were collected for a 24 h period, and whole blood concentrations of diazepam were measured enzyme immunoassay. The mean AUC(0-24) of diazepam was increased 3.2-fold (P < 0.001) and Cmax was increased 1.5-fold (P < 0.05) by the grapefruit juice. Grapefruit juice postponed the tmax of diazepam from 1.50 h to 2.06 h (P < 0.01).
poster:sdb
thread:662997
URL: http://www.dr-bob.org/babble/20060701/msgs/665219.html