Posted by sdb on July 7, 2006, at 21:00:33
In reply to Re: QUESTION..2 mgs. Ativan is equal to?? » Squiggles, posted by MARTY on July 3, 2006, at 23:12:21
> > From benzo.org.uk:
> > also known as Lorazepam, the equivalence is
> >
> > 1-2Ativan : 0.5Klonopin
>
> > http://benzo.org.uk/ (Equivalence Table).
> > Squiggles
>
> Nice equivalence table, bad table cell ;)
>
> Take a look again on the table and you'll see that 1 mg (NOT 1 - 2 mg) of Lorazepam (Ativan) is equivalent to 0.5 mg of Clonazepam (Klonopin).
>
> See ya around
> Marty
>
If you want to change the duration of action and the amount (ng/ml) of clonazepam during time you can simply drink some grapefruit juice (clonazepam is mainly substrate of CYP3A4, grapefruit juice is an "OTC" inhibitor of CYP3A4). The effect of grapefruit juice
on clonazepam, diazepam and other drugs can be up to 24h. Hypericum (St. John's wort) does the opposite and it would lead to faster breakdown of clonazepam (inducer of CYP3A4).
Lorazepam is not substrate of CYP3A4, thus you can not change things with simple methods. Be careful doing that because the change on metabolism will depend on several factors eg. age, liver function, different phenotypes of the CYP3A4, other drugs you take and the dosages. I tested this myself with low dosages and the research is more or less consistent with reality.sdb
poster:sdb
thread:662997
URL: http://www.dr-bob.org/babble/20060701/msgs/664969.html