Posted by Larry Hoover on May 22, 2006, at 18:03:15
In reply to Re: Statistical question on SSRIs - ADDENDUM, posted by linkadge on May 20, 2006, at 2:21:35
> I have actually seen a few clinical trials in which *healthy vaulenteers* were given placebo, or active SSRI. It seemed that the SSRI's were actually producing things like acute apathy, acute akathesia, insomnia, agitation, and suicidal feelings, whereas placebo group experienced no such events.
I can give insulin to healthy volunteers and kill them with it, whereas the target population finds the "drug" to be a wondrous benefit. Perhaps what you are describing is the inappropriate use of the drugs, all the while. Perhaps, if these things happen, you're proving the person didn't need the drug.
Unfortunately, there is no way to know. Not that I can think of, and I've spent a lot of time trying to figure a way. I'd love to prove your hypothesis, one way or the other. I really would. SSRIs nearly killed me. Serzone was perhaps one day from taking out my liver. I really am on your side, link. I only wish we could answer the question. If the evidence was available, I would be thrilled to post it here.
> This is an important type of trial, since in studies such as this we cannot lean back to the old "well this population was depressed anyway".
>
> I have seen reports of psychiatrists self testing SSRI's and having similar findings.
>
> LinkadgeSo long as there is an alternative plausible explanation, then you have not proven your case. I believe I gave a very plausible alternative theory.
Lar
poster:Larry Hoover
thread:640557
URL: http://www.dr-bob.org/babble/20060520/msgs/647046.html