Posted by zeugma on April 20, 2006, at 18:44:25
In reply to Re: Drugs versus Psychotherapy - Backlash?, posted by linkadge on April 20, 2006, at 18:06:26
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> For instance, in this study, which has been replicated in different populations, some researchers found that the double-short varient of the serotonin transporter was associated with a higher lifetime occurance of depression and anxiety disorders. But heres the thing, The SS varient of the serotonin transporter gene codes for a lower reuptake of serotonin.
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> http://www.futurepundit.com/archives/001611.html
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> Some people mistakenly site this as an argument for SSRI use, without noting that this gene actually codes for a lower reuptake of serotonin than those with one or two long varients. So it doesn't make sence to have these people taking SSRI's. Perhaps Tianeptine would bring them to a better homeostasis.
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I agree completely that the double-short variant of the serotonin transporter is associated with a poorer response to SSRI's. This study bears it out:Buspirone or more selective 5-HT1A agonists might be effective in this population, or the new antidepressant (stil in phase III) vilazodone, which is a combined SRI/5-HT1A agonist.
-z
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poster:zeugma
thread:629584
URL: http://www.dr-bob.org/babble/20060417/msgs/635365.html