Posted by linkadge on April 20, 2006, at 17:55:02
In reply to Re: Drugs versus Psychotherapy - Backlash? » linkadge, posted by zeugma on April 20, 2006, at 8:38:06
"The use of a NET inhibitor might bring noradrenergic function in line with that of an individual who was unmedicated but euthymic despite the very different configurations of NET/NE systems in each."
Maybe, or it may even further serve to mask/ intensify an additional, yet unidentified predisposing factor.
Some people even think that the TCA's work independantly of their effects on monoamines. For instance the TCA surmontil has no effect on monoamine reuptake, yet is an effective antidepressant in animal models. It also leads to identical adaptive changes in monoamine receptor sites as other TCA's.
Another argument is that we have drugs such as straterra, which are NRI's but display only weak, negligable effect in depression.
One would think that if the if NET inhibition was the key mechanism, then any drug which inhibited it would be an antidepressnat.
Linkadge
poster:linkadge
thread:629584
URL: http://www.dr-bob.org/babble/20060417/msgs/635352.html