Posted by SLS on April 11, 2006, at 11:50:08
In reply to Re: Parnate is often augmented with Lithium » linkadge, posted by TylerJ on April 11, 2006, at 11:35:51
> If lithium can cause serotonin syndrome when combined w/ maoi's, than surely adding TCA's, and SSRI's will too, or can too, right?
SSRIs are absolutely off limits.
Some TCAs are okay. The safest ones to add are desipramine and nortriptyline. I responded very well to Parnate 60mg + desipramine 150mg. I think Parnate is a bit more forgiving than Nardil when it comes to adding TCAs. Nardil + desipramine is okay, but imipramine is not. You might possibly get away with nortriptyline, but the drug does have weak SRI properties compared to desipramine. Adding desipramine to either drug will produce side effects that are greater in degree. Hypotension and accelerated heart rates occur, but are for the most part of little consequence. These tend to lessen over time.
- Scott
poster:SLS
thread:630791
URL: http://www.dr-bob.org/babble/20060408/msgs/631751.html