Posted by linkadge on April 10, 2006, at 12:49:36
In reply to Re: Parnate is often augmented with Lithium, posted by SLS on April 9, 2006, at 21:01:50
While some doctors choose to augment a MAOI with lithium it I think it has generally been done so with distinct caution. Some reactions have been similar to MAOI-SSRI combinations. Ie serotonin syndrome / seizures.
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http://www.cpa-apc.org/Publications/Archives/CJP/2003/august/bauer.asp
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Effects of Lithium on the 5-HT System in Animals
There is consistent evidence from animal studies that lithium enhances 5-HTergic responsiveness by actions on turnover and release (40–42). Grahame-Smith and Green reported that an increase in 5-HT transmission, produced by enhancing the function of 5-HT neurons, could be demonstrated behaviourally by the appearance of “5-HT syndrome” in rats after short-term application of lithium (43). In their study, the combination of lithium and MAOIs produced a behavioural overactivity syndrome in rats that was indistinguishable from the overactivity evoked by MAOIs and tryptophan. This lithium-induced overactivity syndrome was blocked by prior administration of an inhibitor of 5-HT synthesis (43). Lithium administration was also shown to augment 5-HT release in the rats’ dorsal hippocampus (44) and to enhance 5-HT synthesis (45). Further, short-term administration of lithium also augmented the efficacy of electrically stimulating the ascending 5-HT pathway that suppresses firing of postsynaptic neurons in rats’ dorsal hippocampus (38)After adding 450mg lithium to parnate I experienced severe sweating, shivvering, diareah, confusion, etc. I should have gone to the hospital. I think I passed out, and came to (alive luckily)
Linkadge
poster:linkadge
thread:630791
URL: http://www.dr-bob.org/babble/20060408/msgs/631389.html