Re: Parnate is often augmented with Lithium » linkadge

Posted by TylerJ on April 11, 2006, at 11:35:51

In reply to Re: Parnate is often augmented with Lithium, posted by linkadge on April 10, 2006, at 12:49:36

> While some doctors choose to augment a MAOI with lithium it I think it has generally been done so with distinct caution. Some reactions have been similar to MAOI-SSRI combinations. Ie serotonin syndrome / seizures.
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> http://www.cpa-apc.org/Publications/Archives/CJP/2003/august/bauer.asp
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> Effects of Lithium on the 5-HT System in Animals
> There is consistent evidence from animal studies that lithium enhances 5-HTergic responsiveness by actions on turnover and release (40–42). Grahame-Smith and Green reported that an increase in 5-HT transmission, produced by enhancing the function of 5-HT neurons, could be demonstrated behaviourally by the appearance of “5-HT syndrome” in rats after short-term application of lithium (43). In their study, the combination of lithium and MAOIs produced a behavioural overactivity syndrome in rats that was indistinguishable from the overactivity evoked by MAOIs and tryptophan. This lithium-induced overactivity syndrome was blocked by prior administration of an inhibitor of 5-HT synthesis (43). Lithium administration was also shown to augment 5-HT release in the rats’ dorsal hippocampus (44) and to enhance 5-HT synthesis (45). Further, short-term administration of lithium also augmented the efficacy of electrically stimulating the ascending 5-HT pathway that suppresses firing of postsynaptic neurons in rats’ dorsal hippocampus (38)
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> After adding 450mg lithium to parnate I experienced severe sweating, shivvering, diareah, confusion, etc. I should have gone to the hospital. I think I passed out, and came to (alive luckily)
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> Linkadge
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Is that a pretty high dosage of lithium you were on? That's scary...my pdoc, whom i consider to be extremely competent has mentioned adding lithium to parnate for augmentation purposes.
If lithium can cause serotonin syndrome when combined w/ maoi's, than surely adding TCA's, and SSRI's will too, or can too, right?
Tyler

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Blind Faith In A P Doc Phillipa 4/9/06
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Re: Last thing I should say on this thread » Racer Phillipa 4/9/06
Don't bother -- it's not worth the time. (nm) » Phillipa Racer 4/10/06
Re: Blind Faith In A P Doc » gardenergirl linkadge 4/10/06
Re: Parnate is often augmented with Lithium linkadge 4/10/06
Re: Parnate is often augmented with Lithium Caedmon 4/10/06
Re: Parnate is often augmented with Lithium linkadge 4/10/06
Re: Parnate is often augmented with Lithium linkadge 4/10/06
Re: Blind Faith In A P Doc » linkadge gardenergirl 4/10/06
Re: Parnate is often augmented with Lithium Caedmon 4/10/06
Re: Parnate is often augmented with Lithium linkadge 4/10/06
Re: Parnate is often augmented with Lithium Phillipa 4/10/06
Re: Parnate is often augmented with Lithium » linkadge SLS 4/10/06
Re: Parnate is often augmented with Lithium » linkadge TylerJ 4/11/06
Re: Parnate is often augmented with Lithium SLS 4/11/06
Re: Parnate is often augmented with Lithium linkadge 4/11/06
Re: Parnate is often augmented with Lithium » linkadge TylerJ 4/11/06
Re: Parnate is often augmented with Lithium » TylerJ linkadge 4/11/06
Re: Parnate is often augmented with Lithium » linkadge TylerJ 4/11/06
Augmenting Parnate w/ fish oil » linkadge Caedmon 4/11/06
Re: Augmenting Parnate w/ fish oil » Caedmon linkadge 4/11/06
Re: Parnate is often augmented with Lithium JaclinHyde 4/12/06
Re: Parnate is often augmented with Lithium » JaclinHyde Caedmon 4/12/06
Re: Parnate is often augmented with Lithium » JaclinHyde TylerJ 4/12/06
Re: please rephrase that » Squiggles Dr. Bob 4/13/06
Re: Parnate is often augmented with Lithium JaclinHyde 4/13/06
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Re: thanks (nm) » Squiggles Dr. Bob 4/24/06

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