Psycho-Babble Medication | about biological treatments | Framed
This thread | Show all | Post follow-up | Start new thread | List of forums | Search | FAQ

Re: Parnate is often augmented with Lithium » linkadge

Posted by TylerJ on April 11, 2006, at 11:35:51

In reply to Re: Parnate is often augmented with Lithium, posted by linkadge on April 10, 2006, at 12:49:36

> While some doctors choose to augment a MAOI with lithium it I think it has generally been done so with distinct caution. Some reactions have been similar to MAOI-SSRI combinations. Ie serotonin syndrome / seizures.
>
> --------
> http://www.cpa-apc.org/Publications/Archives/CJP/2003/august/bauer.asp
> --------
>
>
> Effects of Lithium on the 5-HT System in Animals
> There is consistent evidence from animal studies that lithium enhances 5-HTergic responsiveness by actions on turnover and release (40–42). Grahame-Smith and Green reported that an increase in 5-HT transmission, produced by enhancing the function of 5-HT neurons, could be demonstrated behaviourally by the appearance of “5-HT syndrome” in rats after short-term application of lithium (43). In their study, the combination of lithium and MAOIs produced a behavioural overactivity syndrome in rats that was indistinguishable from the overactivity evoked by MAOIs and tryptophan. This lithium-induced overactivity syndrome was blocked by prior administration of an inhibitor of 5-HT synthesis (43). Lithium administration was also shown to augment 5-HT release in the rats’ dorsal hippocampus (44) and to enhance 5-HT synthesis (45). Further, short-term administration of lithium also augmented the efficacy of electrically stimulating the ascending 5-HT pathway that suppresses firing of postsynaptic neurons in rats’ dorsal hippocampus (38)
>
> After adding 450mg lithium to parnate I experienced severe sweating, shivvering, diareah, confusion, etc. I should have gone to the hospital. I think I passed out, and came to (alive luckily)
>
> Linkadge
>
>
>
Is that a pretty high dosage of lithium you were on? That's scary...my pdoc, whom i consider to be extremely competent has mentioned adding lithium to parnate for augmentation purposes.
If lithium can cause serotonin syndrome when combined w/ maoi's, than surely adding TCA's, and SSRI's will too, or can too, right?

Tyler


Share
Tweet  

Thread

 

Post a new follow-up

Your message only Include above post


Notify the administrators

They will then review this post with the posting guidelines in mind.

To contact them about something other than this post, please use this form instead.

 

Start a new thread

 
Google
dr-bob.org www
Search options and examples
[amazon] for
in

This thread | Show all | Post follow-up | Start new thread | FAQ
Psycho-Babble Medication | Framed

poster:TylerJ thread:630791
URL: http://www.dr-bob.org/babble/20060408/msgs/631748.html