Posted by sdb on April 10, 2005, at 16:54:27
In reply to Re: What is wellbutrin (bupropion) pharmacological, posted by mattw84 on April 10, 2005, at 15:24:05
Hi mattw84,
Yes, serotonin plays a major role in the whole body. But in spite of the minor 5% i think it definitaly plays a major role in defined locations of the brain always involved with all other neurotransmitters, receptors. The receptors define the effect not the ligand per se.
I suppose the priapism is likely more caused by the high affinity or even downregulation for alpha1-receptors in arteries in the cavernosus of the penis.
Your state sounds interesting. I have never heard Wellbutrin could be usefull for bp and is effective even in sp.
I think I will give the Wellbutrin a try in a low dosage to see what it does. I have never taken it yet and I am totally unexperienced. But I am anyway pleased to take something different. It seems to be a drug, which can often produce different reactions in individuals. Bupropion is highly metabolized by the liver.
I would be interested in more information, if bupropion works more through dopamine transmission or noradrenaline transmission (I dont like to much central norepinephrine transmission)
Interestingly, if bupropion works in specific locations in dopamine transmission it could lead to abuse.
Thanks for your advice,
sdb
poster:sdb
thread:481676
URL: http://www.dr-bob.org/babble/20050408/msgs/482448.html