Posted by mattw84 on April 10, 2005, at 15:24:05
In reply to Re: What is wellbutrin (bupropion) pharmacological, posted by sdb on April 10, 2005, at 3:39:23
Sdb,
You are correct in that wellbutrin tends to be quite anxiogenic for patients predisposed for it. However, in spite of this it is still the 'best' AD for bipolar individuals as it is the least likely trigger manic episodes.
Interestingly enough -- though not a labelled or off-label treatment for social anxiety, previous studies show that it is effective for this indication in many cases... Quite the paradox to what one would anticipate.
Trazadone on the other hand, has amongst the highest affinities for serotonin , which people tend to attribute only to it's influence on emotion. In fact -- only 5% of one's serotonin is found in the brain. This chemical also controls many other functions in the body. The cause of priapism can likely be explained by the vasoconstrictive properties of serotonin. It also plays many other roles in the body, thus the numerous unwanted and often unexplainable side-effects of tricyclic and heterocyclic antidepressants...
Looks like you may already have answered your own question. =) None-the-less, I hope this helps shed some more light on the subject.
Regards,
Matt
poster:mattw84
thread:481676
URL: http://www.dr-bob.org/babble/20050408/msgs/482409.html