Posted by sdb on April 10, 2005, at 3:39:23
In reply to Re: What is wellbutrin (bupropion) pharmacological, posted by mattw84 on April 9, 2005, at 18:33:21
Thank you matt for your response.
Bupropion seems to resemble to Cocaine!
So, I think its more activating and not good to combat anxiety. But the fact that it has minor effect on noradreanline transmission seems to be a positive effect (for people with anxiety in depressive episodes).
Where have you read that bupropion only has minor effect on noradrenaline transmission? -I dont like noradrenaline transmission because its causing tremor, tachycardia. For depressive individual this is ok (activating), but for bp with anxiety it is not. I had this experience with mirtazapine, which when plasma levels rose increased noradranline transmission and i had a terrible panic attack!
I am not experienced with dopamine enhancing drugs. One positive aspect is that trazodone increases indirectly steroid production in adrenal gland (!) trough 5ht2 affinity and therefore secretion of acth from the pituitary gland (more libido). And second positive aspect is the approx. 1/10 alpha2/alpha1 blocking properties which dilates blood vessels in sinus cavernous (pro erectional).
poster:sdb
thread:481676
URL: http://www.dr-bob.org/babble/20050408/msgs/482259.html