Posted by don_bristol on July 29, 2004, at 6:02:21
In reply to Re: How late in afternoon should I take Parnate?, posted by King Vultan on July 28, 2004, at 7:45:40
King Vultan (Todd) wrote:
>> It's the MAO inhibition that is more important than the actual half life. That is, the major effect of the drug is to inhibit monoamine oxidase, a molecule of which is permanently rendered useless once the Parnate bonds to it. That effect will continue long after the 1.5 to 3 hour half life. <<
Todd, you make a good point that it is the MAO inhibition that is more important than the actual half life of the compound.
Do you know how long this MAOI inhibitory effect lasts for after a dose of an MAOI like Parnate?
It can't last all that long because all the recommendations I have seen for Parnate include a second dose each day.
Often the recommended timing of this second dose is only a five or six hours after the first one. So I guess that those few hours could be significant.
poster:don_bristol
thread:371535
URL: http://www.dr-bob.org/babble/20040724/msgs/371936.html