Posted by King Vultan on July 28, 2004, at 7:45:40
In reply to How late in afternoon should I take Parnate?, posted by don_bristol on July 28, 2004, at 6:56:41
> How late in the day are you people taking Parnate?
>
> The Patient Information Leaflet which come with my Parnate here in the UK says to take the second (last) dose at 3 p.m.
>
> To me 3 p.m. seems early. In order to spread the dose out, I try and take my Parnate as late as possible because I read that Parnate's half-life is short at 1.5 to 3 hours.
>
> DonIt's the MAO inhibition that is more important than the actual half life. That is, the major effect of the drug is to inhibit monoamine oxidase, a molecule of which is permanently rendered useless once the Parnate bonds to it. That effect will continue long after the 1.5 to 3 hour half life.
I think it's wise to spread the dosages out as much as possible for maximum MAO inhibition efficiency, as well as to spread out the stimulatory effects of this drug and avoid the possibility of a spontaneous hypertensive crisis. As for when the last dose should be taken, I would not take it so late that it screws up your sleep. My plan for when I am on 3 x 10 of this probably in early September will be to take 1 pill each at 6 AM, Noon, and 5 PM, but I can always modify this a little if necessary.
Todd
poster:King Vultan
thread:371535
URL: http://www.dr-bob.org/babble/20040724/msgs/371541.html