Posted by Ron Hill on June 15, 2003, at 14:05:14
In reply to NADH question » Ron Hill, posted by Ritch on June 14, 2003, at 10:19:43
Hi Mitch,
> I'm just taking a regular multivitamin, with a B-complex, 500mg of tyrosine, and some fishoil-supplementwise. I've read bits here and there about the ENADA NADH. I'm a little hesitant to try it because I am so susceptible to temper spells.
Your reluctance is understandable since ENADA NADH causes irritability in most people in a dose dependent fashion. Two add-on supplements have allowed me to resolve my bipolar related irritability (dysphoric mood states) and the ENADA NADH induced irritability. The two supplements are niacin (or niacinamide) and, to a lesser extent, TMG.
The benefit I find in adding TMG is that it seems to extend the time period of effectiveness for a given dose of ENADA NADH. In other words, without TMG, a 2.5 mg dose of ENADA NADH loses its effectiveness after about four days. But with TMG, it can last for almost a week. Therefore, TMG indirectly reduces my irritability by reducing my ENADA NADH dosing frequency. I think TMG is also providing a mild antidepressant effect.
However, the supplement that fixed my irritable (dysphoric) mood states is niacin. I currently take 125 mg of niacin twice or three times a day. The effect is profound. I plan to try niacinamide (either in addition to or in place of niacin) since the research indicates that niacinamide is better for irritability than niacin. The addition of niacin allows me the flexibility of taking 2.5 mg of ENADA NADH twice a week if I need the more frequent dosing to manage my atypical depressive symptoms.
> What maintenance dose are you on now?
I take 2.5 mg once or twice a week depending on how I feel. When the ENADA NADH dose begins to wear-off, I know it right away. I begin to lose my motivation and energy and I start to feel like I could slip back into my atypical depressive state. I try to stretch the dose as far as it will go because I’m of the belief that the risk of supplements losing their effectiveness can be reduced by minimizing the dosage and dosing frequency, and by taking holidays.
During the acute treatment phase of my atypical depression, I took 10 mg/day of the sublingual ENADAlert NADH. However, after ten days the initial dose began to cause bothersome irritability. It is my opinion that I needed the higher dose to pull me out of the very severe depression that I was in at the time. But the higher dose is not sustainable (nor needed) long-term. As an aside, my depression began to lift within 10 seconds of placing the first sublingual tablet under my tongue.
My theory is that the primary reason ENADA NADH (coenzyme one) is such a great benefit to me is because of its dopaminergic effects. However, in addition to its various functions throughout the body, coenzyme one also plays a role in the intercellular energy production process (i.e.; ATP production and utilization) and this feature might also be a factor in the equation regarding its effectiveness in treating my atypical depression. One cautionary note about my theories; they are always subject to change without notice.
Mitch, what symptoms of your BP II are you thinking ENADA NADH might help alleviate?
> You're using the enteric coated stuff, right?
Right.
-- Ron
poster:Ron Hill
thread:102831
URL: http://www.dr-bob.org/babble/20030614/msgs/234135.html