Re: Starting trimipramine (Surmontil) next week.

Posted by Caleb462 on May 22, 2003, at 2:05:40

In reply to Starting trimipramine (Surmontil) next week., posted by SLS on May 21, 2003, at 21:56:31

> Hi.
>
> I'll be starting trimipramine (Surmontil) next week. It is a tricyclic antidepressant that is supposed to be sedating. That sucks. Sedation only compounds the problems I have functioning on a day to day basis. Does anyone know if the sedation eventually wears off?
>
> I am marginally responsive to other tricyclics like imipramine and amitriptyine. However, trimipramine is an odd-ball TCA because it does not inhibit the reuptake of serotonin or norepinephrine. Does anyone know how it works? Mysterious.
>
>
> - Scott
I've done a little research, and apparently, trimipramine acts much like an atypical anti-psychotic, by effectively blocking 5-HT2 and dopamine receptors. 5-HT2 antagonism has been shown to cause an anti-depressant/anxiotylic response, so that is one possible mechanism. Also, trimipramine has some anti-cortisol properties which may have something to do with it's AD effect.
Overall though, it seems to be quite the mystery drug.

Thread

Starting trimipramine (Surmontil) next week. SLS 5/21/03
Re: Starting trimipramine (Surmontil) next week. Caleb462 5/22/03
Re: Starting trimipramine (Surmontil) next week. » SLS Ron Hill 5/22/03
Re: Starting trimipramine (Surmontil) next week. » Ron Hill SLS 5/22/03
Re: Starting trimipramine (Surmontil) next week. » Caleb462 SLS 5/22/03
Re: Before you start your trimipramine (Surmontil) » SLS Ron Hill 5/22/03
Re: Starting trimipramine (Surmontil) next week. » SLS Jack Smith 5/22/03
Re: Starting trimipramine (Surmontil) next week. stjames 5/23/03
Re: Starting trimipramine (Surmontil) next week. Caleb462 5/23/03
Re: Starting trimipramine (Surmontil) next week. stjames 5/23/03

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