Posted by JohnX2 on February 22, 2002, at 22:44:44
In reply to Re: selegiline stuff, posted by Jason911 on February 22, 2002, at 15:38:36
Hi Jason911 (sounds like a tv show),A lot of people report that Wellbutrin feels
like amphetamines when it kicks in. This is a dopaminergic
buzz. This is certainly the feeling that I got when it worked
for me. How long have you been on Wellbutrin?
You need to wait for upto 4 weeks for the medicine to
take effect. This is of course how antidepressants work. Deprenyl may feel
better quicker, but Wellbutrin may be a better soultion long run.
Anways, when the Wellbutrin works, you will feel a light bulb turn
on. In the mean time you may feel more energetic and less depressed
(and more anxious). This is the noradrenaline reuptake mechanism.
Over time the anxiety should wear down. This is the nature of antidepressants.
You will have side effects at first, and then the goodies come later.
Bummer. In the animal studies of Wellbutrin, it was found that the
principal metabolites did elicit behavior consistent with dopaminergic
mechanisms. Also, there was a net decrease in anxiety for those that
elicited a response (I read a big long gory technical paper on the medicine).
I've tried both Wellbutrin and Deprynl. I found that Wellbutrin long run
was better for my anxiety and I didn't have to watch my diet for tyramine.good luck,
John> I basically, think the Wellbutrin is working, but at a dose that causes anxiety! All this while I'm on Klonopin for anxiety. I think I need Deprenyl, or something other than an SSRI, that can improve my mood and not interfere with anxiety. I got word last night that he wanted me to take 1mg in the morning .5mg at noon and 1mg before bed. Is it best to separate them??? Because I only get the effect on at least 2mg at once! This pisses me off. He increases Wellbutrin, and he is so adament about the fact that that is THE drig of choice when it comes to Dopamine-related depression. I hate Wellbutrin because my anxiety is back up even though I'm feeling better, basically due to the dopaminergic action (what ever it is), I need something do help the dopamine (I think the lwo dose (5mg) deprenyl would give a nice pick-me-up along with the relaxation of the Klonopin (which I want raised). It seems I am going towards the category of treatmen-resistant. I always need a large amount to get whatever I'm taking to work. Anyway, talk back guys, love to hear from you! -Jason911
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> > Hi. Here's the best information I have that might apply to your situation.
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> > At higher doses, selegiline i a nonselective MAOI. At lower doses, I'm not sure it will do much for you, although it's worth trying.
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> > The MAO-B isoenzyme acts preferentially on dopamine, as you surmised; and selegiline is a MAO-B inhibitor at low doses (and becomes nonselective at higher doses). In contrast, nobody really knows what Wellbutrin does, although it's pretty well known that Wellbutrin exacerbates anxiety.
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> > > My anxiety attacks have actually gotten a little worse.
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> > That could easily be from the increased Wellbutrin. Ritch also has a good point; if you're raising the WB, you might want to wait on the selegiline, or vice versa. Selegiline and its active metabolites (l-amphetamine and l-methamphetamine) can certainly have sympathomimetic effects. Monitoring your blood pressure and heart rate seems warranted.
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> > The seizure risk is not so much of a concern; selegiline actually has been found to have marked anticonvulsant effects (this has been studied in lab animals using pentylenetetrazole-induced seizures).
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> > > Past 4 days I've been taking 2mg at one time at noon. I begin to feel quite good and I feel a balance with my mood and anxiety now but wears off my 6 or so.
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> > That's odd. I've found that Klonopin lasts a good 8 hours, at least. (Or do you mean 6 am?)
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> > > So I think I still need more klonopin.
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> > Or maybe you need to divide the dose more? For example, 0.5 in the morning, 0.5 in the afternoon, 1 at bedtime. I found 4 mg/day (1 morning, 1 afternoon, 2 bedtime) to be optimal for me when I was taking it.
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> > The vision thing is weird and could be caused by the Wellbutrin. That's just a guess, of course.
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> > > I'm getting the impression that selegiline plus benzos actually benefit from each other and leaves you feeling great.
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> > I'd expect them to complement one another, with the benzos alleviating the jitters from selegiline. Anyway, low-dose selegiline (5-10 mg) might well be of help to you, although IIRC there's much more evidence for high-dose selegiline (in depression, at least).
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> > > Everybody reply and tell me if I'm going the wrong way or something, because I also think the Wellbutrin with deprenyl won't hurt.
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> > The cardiovascular risk would be my main concern. Serotonin syndrome isn't a problem (as it can be with other ADs -- it even occurs occasionally with low-dose selegiline, I think); one thing that is known about Wellbutrin's mechanism of action is that it's not a serotonergic drug.
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> > I'll be interested to hear how the selegiline works for you. I never tried taking a low dose, although I did once try a high dose (too jittery).
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> > -elizabeth
poster:JohnX2
thread:95046
URL: http://www.dr-bob.org/babble/20020222/msgs/95169.html