Posted by tina on November 1, 2001, at 22:39:37
In reply to Re: Tired and sleepy on Moclobemide (Manerex) » JohnX2, posted by adamie on November 1, 2001, at 20:27:11
I was on Manerix for 3 years and it didn't make me tired either. I was on 600mg a day and it didn't matter when I took it.
Must be an interaction thing. I hope it works out for you. I did find that it took about 8 weeks to get any benefit from the moclobemide.>
> thanks for the info
>
> > This may be relavent, it is from looking up
> > some quick information on drug interactions.
> >
> > Both Manerix and Zyprexa are metabolized by
> > cyp450-1a2. I believe that both meds can have serious interactions
> > with drugs that inhibit cyp450-1a2 like cimitidine.
> > Zyprexa is also metabolized by cyp450-2d6, which
> > manerix may inhibit (according to a chart I have),
> > but I wouldn't venture to guess the net sum
> > of interactions.
> >
> > The drug interactions between Manerix and these
> > newer meds are not well studied. Could be they
> > are competing for the same enzyme substrate and
> > this is increasing the zyprexa in your body.
> > I dunno.
> >
> > I found that Manerix had an anti-anxiety affect,
> > but it didn't make me tired. It didn't seem to
> > matter much for me when I dosed it either. But
> > this is me, and Manerix was the only med I was
> > on.
> >
> > -john
> >
> >
> >
> > >
> > > hi. I have been on Moclobemide for my 3rd day now (also on zyprexa for 2 weeks or so). All AD's I've tried before this have made my depression worse. I cant tell yet if that is happening with the Moclobemide. But I am much more tired and sleepy than usual. Should I take my two doses of 300mg in the night time? I currently take my first dose around 12:30pm and the second around 8pm. I am the most tired around 4pm. I take my zyprexa 5mg around 10pm. Would it be okay to take a moclobemide dose along with the zyprexa? And then perhaps take my second dose at 11:30pm before going to sleep. Or maybe at 9pm and then at 11:30pm.
poster:tina
thread:82883
URL: http://www.dr-bob.org/babble/20011025/msgs/82935.html