Posted by adamie on November 1, 2001, at 20:27:11
In reply to Re: Tired and sleepy on Moclobemide (Manerex) » adamie, posted by JohnX2 on November 1, 2001, at 16:37:52
thanks for the info
> This may be relavent, it is from looking up
> some quick information on drug interactions.
>
> Both Manerix and Zyprexa are metabolized by
> cyp450-1a2. I believe that both meds can have serious interactions
> with drugs that inhibit cyp450-1a2 like cimitidine.
> Zyprexa is also metabolized by cyp450-2d6, which
> manerix may inhibit (according to a chart I have),
> but I wouldn't venture to guess the net sum
> of interactions.
>
> The drug interactions between Manerix and these
> newer meds are not well studied. Could be they
> are competing for the same enzyme substrate and
> this is increasing the zyprexa in your body.
> I dunno.
>
> I found that Manerix had an anti-anxiety affect,
> but it didn't make me tired. It didn't seem to
> matter much for me when I dosed it either. But
> this is me, and Manerix was the only med I was
> on.
>
> -john
>
>
>
> >
> > hi. I have been on Moclobemide for my 3rd day now (also on zyprexa for 2 weeks or so). All AD's I've tried before this have made my depression worse. I cant tell yet if that is happening with the Moclobemide. But I am much more tired and sleepy than usual. Should I take my two doses of 300mg in the night time? I currently take my first dose around 12:30pm and the second around 8pm. I am the most tired around 4pm. I take my zyprexa 5mg around 10pm. Would it be okay to take a moclobemide dose along with the zyprexa? And then perhaps take my second dose at 11:30pm before going to sleep. Or maybe at 9pm and then at 11:30pm.
poster:adamie
thread:82883
URL: http://www.dr-bob.org/babble/20011025/msgs/82931.html