Posted by jay on September 23, 2001, at 8:12:56
In reply to Re: Monominergic theories could be horse hockey » jay, posted by SLS on September 22, 2001, at 20:08:51
> > You will have to look at the book for sources, but he mentions that within one day of starting anti-depressants, both the neurochemical *and* receptor changes occur...
>
>
> He is wrong.
>
> It is well documented that the turnover rate of neurotransmitter receptors along the cell membrane is approximately two weeks - just about the time it takes for downregulation to occur in response to antidepressants - just about the time it takes for someone to respond to these antidepressants. Whether or not some types of receptors are changed in some way immediately, it is indisputable that changes in the binding characteristics of many monoamine receptors (NE beta-1, NE alpha-1, NE alpha-2, 5-HT1a, 5-HT2, etc.) and the behavior of many postsynaptic second-messenger events are latent and associated with the chronic, but not acute, administration of antidepressant drugs.
>
>
> - Scott
Well, that is your view. Read Peter Whybrow's "A Mood Apart" for discussion on the immediate changes of receptor sensitivity after a.d. administration. You are talking about the *complete* process of regulation, but that is old news. Why do some a.d.'s work, that don't even touch NT levels? More questions than answers.Jay
poster:jay
thread:79238
URL: http://www.dr-bob.org/babble/20010917/msgs/79368.html