Posted by jay on September 22, 2001, at 17:55:13
In reply to Re: Monominergic theories could be horse hockey, posted by stjames on September 22, 2001, at 14:40:57
In Andrew Solomon's new book "The Noonday Demon", he mentions that both the monoamine *and* receptor up/downregulation theories are questionable. You will have to look at the book for sources, but he mentions that within one day of starting anti-depressants, both the neurochemical *and* receptor changes occur...yet they say it still takes a month or two for your symtoms to lift.
He mentions that it likely has to be some major shifts in massive amounts of bodily hormones, as well as things like areas of brain activity, that eventually change after much repeated a.d. use.
As he lastly states, using simple theories like the monoamine theory is like the ancient theories that mental illness was caused by "vapours".
Jay
> > I am not saying they are for everybody. But they could be useless. I know with my form of depression. Levels of seretonin,dopamine and NE are not a factor. Its a dysfunction in my circadian rythmn. Monominergic theories have been around for 50 + years and they are no closer to being proven than ever. Keep well, look after yourselves.
>
> James here.....
>
> Monoamines have everything to do with one cause of depression. Given that every AD effects them, clearly Monoamines have something to do with mood. No question here. It is "horse hockey" to
> say that is a lack (or too much) of a Monoamine that causes mood problems, by themselves. This is where the theory fails as it is not complex enough.
>
> james
poster:jay
thread:79238
URL: http://www.dr-bob.org/babble/20010917/msgs/79322.html