Posted by SLS on September 22, 2001, at 20:08:51
In reply to Re: Monominergic theories could be horse hockey » stjames, posted by jay on September 22, 2001, at 17:55:13
> You will have to look at the book for sources, but he mentions that within one day of starting anti-depressants, both the neurochemical *and* receptor changes occur...
He is wrong.It is well documented that the turnover rate of neurotransmitter receptors along the cell membrane is approximately two weeks - just about the time it takes for downregulation to occur in response to antidepressants - just about the time it takes for someone to respond to these antidepressants. Whether or not some types of receptors are changed in some way immediately, it is indisputable that changes in the binding characteristics of many monoamine receptors (NE beta-1, NE alpha-1, NE alpha-2, 5-HT1a, 5-HT2, etc.) and the behavior of many postsynaptic second-messenger events are latent and associated with the chronic, but not acute, administration of antidepressant drugs.
- Scott
poster:SLS
thread:79238
URL: http://www.dr-bob.org/babble/20010917/msgs/79334.html