Posted by kregpark@yahoo.com on September 1, 2001, at 5:03:18
In reply to Re: MAOIs and safety, posted by IanSFO on August 29, 2001, at 19:41:29
Hi IanSFO:
I'll throw in my 2 cents also.
About the dangers of MAOI interactions:
I have taken Nardil for about 5 years total, 2 years at a high dose, (90 mg) and 3 years at a mild dose (60 mg).
My personal opinion is that serotonin syndrome is the main risk for most MAOI users, but I also think the risk of serotonin syndrome goes for anyone on a serotonergic (almost every antidepressant sold!).
Basically any two antidepressants should be used together with caution (even single drug remigmens like Paxil and Effexor have led to serotononin syndrome deaths).To Nardil, I have cautiously added (incrementally increasing dose) of stimulants or stimulant like meds such as Ritalin, Dexedrine, amantadine, Wellbutrin, amineptine, tianeptine, PROVIGIL, yohimbine, caffeine pills (part of my regimen actually); also Serzone (this one can make Nardil much like Parnate!!!), and others...
None of these led to any notable change in BP (I measured anything potentially risky). Max raise I got was maybe 5 points. BP LOSS is much more common for me with these, enhanced dopaminergic as well as the more complex Norepinephrine effects.Anyway, long story a bit less long:
Many drugs can be dangerous. Being prudent (avoid certain wines, large quantities import beer, huge chunks of cheese, and most of all serotonergic antidepressants or drugs) -
Relative safety is good as you'll see on Medline or by calling manufacturuers.Driving to your docs office is likely factors of 10 times more dangerous than all your years of MAOI!!!
KregPark@yahoo.com
http://www.socialfear.com
> Thanks for the replies to my post. It always seemed ironic to me that hypertensive crisis was a concern with a drug that tended to lower your blood pressure. My first night on Parnate my blood pressure dropped to 75 over 35! I was a bit unnerved and called a free medical information line to be sure I wasn't in danger.
>
> But I'm still wondering about the relative danger of decongestants and MAOIs, since tyramine is not an issue.
>
> I'm also curious about the potential for drug interactions when using the deprenyl patch. Bypassing the digestive system may eliminate the danger of tyramine reactions, but does it eliminate dangers from drug reactions? Does anyone know?
>
poster:kregpark@yahoo.com
thread:76778
URL: http://www.dr-bob.org/babble/20010828/msgs/77231.html