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Re: MAOIs and safety » IanSFO

Posted by Elizabeth on August 31, 2001, at 15:11:04

In reply to Re: MAOIs and safety, posted by IanSFO on August 29, 2001, at 19:41:29

> But I'm still wondering about the relative danger of decongestants and MAOIs, since tyramine is not an issue.

I don't think it's fair to say that tyramine isn't an issue; it's just an issue that's been overplayed. Systemic decongestants (like Sudafed) are a problem with MAOIs; nasal sprays (Afrin, etc.) are generally okay since they act locally (even if some got into your bloodstream, the concentration would be insignificant).

> I'm also curious about the potential for drug interactions when using the deprenyl patch. Bypassing the digestive system may eliminate the danger of tyramine reactions, but does it eliminate dangers from drug reactions? Does anyone know?

Yes. There can be drug interactions with transdermally administered selegiline.

-elizabeth


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