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Re: Buprenorphine Question » Elizabeth

Posted by jojo on August 3, 2001, at 2:28:31

In reply to Re: Buprenorphine Question » jojo, posted by Elizabeth on August 3, 2001, at 0:01:23

> > I'm sorry. Of course it's 1.2 mg., not 12 mg.
>
> Ahh!
>
> > Of course, when I used the drops from the syringe (after removing the needle) I lay
> > down with my neck hyperextended, and of course it was an empty
> > Afrin metered sprayer before I washed it and added the buprenorphine.
>
> Right; I'm just making the point that Afrin acts locally, so you don't have to worry about trying to get it into your system. I don't think that buprenorphine is actually absorbed primarily through the mucous membrane; my understanding is that there's a bundle of blood vessels somewhere back there and buprenorphine enters the bloodstream through that.
>
> Did buprenorphine work when you took it using a syringe (sans needle, I hope)?
>
> > Why do you insist that it's not working? Because I'm not aware of any affects
> > or effects other than the early constipation?
>
> Yes, actually. My guess is that it's not being absorbed very well.
>
> > I think that indicates that it IS working.
>
> Uhh...I'm not following your reasoning here.
>
> > Actually, I think it's working very well. An antidepressant that prevents or induces
> > recovery from depression without one feeling any ill or "side effects" seems to be the ideal drug.
>
> It's not clear to me that the buprenorphine is what's keeping you from becoming depressed. My understanding is that you started it shortly after discontinuing the Celexa. Not everybody will necessarily become depressed or "crash" shortly after discontinuing an AD; it depends on the severity and chronicity of the depression (and just general individual differences). For all I know, you might be feeling fine if you were not taking the buprenorphine. The pattern you described just doesn't sound typical compared to other people who've taken and responded to buprenorphine. I'd expect it to cause some degree of mood elevation in nondepressed people, not just in depressed people or addicts. If you didn't "crash" after stopping the Celexa, I'm assuming you weren't depressed when you started the buprenorphine; but I'd still expect some very noticeable effects.
>
> -elizabeth

You're right, I wasn't highly depressed when I was on the Celexa. I switched to buprenorphine in the hope of at least maintaining my "Celexa mood", but hoping to avoid the Celexa sexual effects. A good orgasm once in a while is very high on my "wish list".

In the past, I've crashed 4-6 weeks after stopping a somewhat successful AD (Elavil, Prozac, Celexa, but not Remeron. Wellbutrin , trazadone. Effexor ). It's now been a month since stopping Celexa and starting buprenorphine.

I think the fact that I developed constipation, and felt buzzed the first few days indicates that absorption is occurring. Also. Adding Yohimbine, 5.4 mg. tid may be making a contribution. It has some AD and activating properties, so much so that I almost never take Dexedrine any more. BTW, no withdrawal effects from stopping the Dex.

"Did buprenorphine work when you took it using a syringe (sans needle, I hope)?"

I'm not sure what "work" means here. I felt the reaction that I described . I feel decent enough generally, possibly somewhat better than I did with Celexa alone (BTW, I also added 900 mg./day of Neurontin around the same time as the big switch. I know this is not scientific, but I don't have 50 years to be more systematic and test each drug separately for 6-8 weeks. I try a recipe that seems reasonable, and hope that I'll be lucky.), and sometimes I feel "pretty good. If this were a poker game, I'd stick with this hand so far.
What very noticeable effects would you expect? The ache in my shoulder went away within the first hour of the first dose.

jojo


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