Posted by Elizabeth on August 1, 2001, at 14:14:06
In reply to Re: Buprenorphine Question » Elizabeth, posted by jojo on July 31, 2001, at 21:21:44
> 0.1 cc out of 1.0 is still only 10%, and since I don't feel its effects or affects
> (must be that injection of Xylocaine I take beforehand ; >) ... ). I'm sitting up, of
> course. How else does one use a "spray" bottle, you silly goose!Well, that might be why it's not working; try lying down with your neck hyperextended, and stay in that position for a couple of minutes after taking the buprenorphine. Afrin is a locally-acting drug; buprenorpine is not.
(BTW: I'll cop to silly, but I'm no goose.)
> Unless I just haven't crashed yet (I shudder at the thought), it appears to be a very
> effective "antidepressant", and after one month, the only "side effects" seem to be a
> little constipation during the first few days.That makes me think even more that it's not getting absorbed.
> As this is REALLY off label, and there have only been a few publications, how do we
> know that 12 mg. per day is the appropriate dose. Your impression is that one feels
> the effect in an hour or so. I can always take another hit.12 mg? That's an awful lot -- like, 40 mL, a volume that is ill-suited for intranasal (or IM) administration, even if you're taking it in many divided doses. Are you really taking it every 2 hours? Do you sleep???
BTW, it might work faster (than 1 hour after each dose, that is) if you reach steady state. I probably don't have much of a steady-state concentration because I can't take it at bedtime (too activating).
-elizabeth
poster:Elizabeth
thread:72061
URL: http://www.dr-bob.org/babble/20010731/msgs/72918.html