Posted by jojo on July 31, 2001, at 1:08:09
In reply to Re: Buprenorphine Question » jojo, posted by Elizabeth on July 30, 2001, at 16:41:15
> > I'm drawing 1.0 ml. into a 3.0 ml syringe, and dripping this into my nostrils, usually 10
> > drops
> > (about 0.5 ml. every 2-3 hours).
>
> The way I was instructed to do it was to lie down and tilt my head back (i.e., hyperextend it). I've tried doing it sitting up, and it doesn't seem to work very well. Ideally you should only need to take it every 4-6 hours.
>
> > The first few days I felt somewhat "buzzed", but since then am not aware of any
> > sensation. If there are no adverse sexual effects, and I continue to feel as good, this
> > may be the ideal antidepressant for me.
>
> I felt a little dizzy and lightheaded the first couple of times I took it, too.
>
> So, may I ask how you came to have your beta-endorphin levels tested??? :-)
>
> -elizabethSorry, I can't pass this one up.
"The way I was instructed to do it was to lie down and tilt my head back (i.e.,
hyperextend it). I've tried doing it sitting up, and it doesn't seem to work very
well. Ideally you should only need to take it every 4-6 hours."I've always had trouble taking nose DROPS sitting up, especially using a syringe and
needle.An Afrin pump dispenser provides 1 ml in 7-8 sprays. Besides, it looks a lot more
innocuous!Re: Beta Endorphin test. My first success in psychopharmacology, showing there
was some reasonable hope of recovery after possibly 9 years of severe depression,
while being treated by 3 Psychoanalysts in succession. The first one (5 years, 4-7
times per week), believed Freud, and carefully quoted him to me, who said
'depression is often anger turned inward'. May sometimes be true, but I don't know if
this is the major factor. Anyway, suicide seemed the most realistic solution, when I
read an article in (possibly)
the American Journal of Psychiatry, dealing with some 'borderline personality
cohorts, who had elevated levels of Beta Endorphin, and responded positively to
L-Dopa. The author's explanation had to do with chronic stimulation of receptors,
which doesn't seem to be the case, but some of their symptoms (anergia, anhedonia
and maybe a few more) reminded me of myself, so I called my old shrink, sent her a
copy of the article, and she was not too threatened by this to give me a prescription
of L-Dopa, and a lab test for Beta Endorphin. The Endorphin came in low (it's still not
clear if that is significant, or what meaning it had), but the L-Dopa worked nicely (for
me - to me it looked like up!) for 3 months, at rather low doses, until I awoke one
morning the lowest I've ever felt...but that's a long story. Anyway, I knew that
psychopharmacology could work, which is why, I suppose, I am hear to write this
today.BTW, this raises some interesting questions about patient selection, and results from
"spontaneous remission' and "placebo effect".
With outpatients chosen "at random", it is said that 1/3 get better "spontaneously, 1/3
respond to placebo, and 1/3 respond to medication. If, in a particular situation it
seems proper to add the results from the placebo group to that of the spontaneous
group, than only 1/3 show an actual response to the AD being tested, which is about
the same results achieved with L-Dopa, which, I believe was 40%. Is it me or others
who may be missing something here. Depends on the patient selection, of course.
No Psychiatrist to whom I have mentioned this seemed even slightly intrigued.jojo
poster:jojo
thread:72061
URL: http://www.dr-bob.org/babble/20010725/msgs/72676.html