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Re: My Disappointment here + My early years undopaminergic

Posted by Jay2112 on September 5, 2021, at 19:27:00

In reply to Re: My Disappointment here + My early years SLS, posted by undopaminergic on September 3, 2021, at 8:35:44

> >
> > The second finding that I came across accidentally is that lithium has a bimodal effect on glutamate activity. At low dosages, it increases activity, whereas higher dosages reduce activity. There is some speculation that glutamate activity is associated with mood states. Glutamate is the most pervasive excitatory neurotransmitter. Too much glutamate is thought by some to be a contributing cause of mania. Conversely, too little activity might contribute to the depressive state.
> >
>
> If so, I have to ask why memantine, a NMDA-glutamate receptor antagonist, can induce mania for me?
>
> Obviously, given that glutamate is the brain's major excitatory neurotransmitter, its neurology is likely complex. Ie. glutamate in one part of the brain does one thing, and glutamate in another part does another thing, possibly opposing each other.
>
> -undopaminergic
>

Hi U-D:

I believe memantine is closely related to amantadine? Amantadine is a dopamine agonist, so memantine may share some of amantadine's dopamine agonism, which of course will send you orbiting.

Just a thought..

Jay


Humans punish themselves endlessly
for not being what they believe they should be.
-Don Miguel Ruiz-


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poster:Jay2112 thread:1116650
URL: http://www.dr-bob.org/babble/20210723/msgs/1116842.html