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Re: My Disappointment here + My early years Jay2112

Posted by undopaminergic on September 6, 2021, at 3:49:39

In reply to Re: My Disappointment here + My early years undopaminergic, posted by Jay2112 on September 5, 2021, at 19:27:00

> >
> > If so, I have to ask why memantine, a NMDA-glutamate receptor antagonist, can induce mania for me?
> >
> > -undopaminergic
> >
>
> Hi U-D:
>
> I believe memantine is closely related to amantadine?

Yes, memantine is dimethyl-amantadine.

> Amantadine is a dopamine agonist, so memantine may share some of amantadine's dopamine agonism, which of course will send you orbiting.
>

I'm my view, amantadine is also a NMDA-glutamate antagonist, but weaker than memantine. I don't agree that amantadine is any kind of serious dopamine-reuptake inhibitor, which one study claims it is. It is only *functionally* a dopamine agonist, by means of the NMDA-inhbitory action.

-undopaminergic


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