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Re: What is OCD? phidippus

Posted by ed_uk2010 on February 14, 2015, at 9:49:31

In reply to Re: What is OCD? ed_uk2010, posted by phidippus on February 14, 2015, at 0:51:29

>Some of these agents include Keppra, Riluzole, Zonegran, Lamictal, Lyrica, Neurontin and Topomax. Trileptal would not be suitable because it is not anti-glutamatergic.

According to the studies on PubMed, it seems that all the AEDs which act as Na+ channel blockers, including oxcarbazepine (Trileptal), inhibit the release of glutamate. Carbamazepine (Tegretol), oxcarbazepine, lamotrigine (Lamictal) and phenytoin are among the most potent and widely used Na+ channel blockers, but several other AEDs have this property too. To what extent inhibiting glutamate release is useful in OCD is not well understood, it seems.

 

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poster:ed_uk2010 thread:1075804
URL: http://www.dr-bob.org/babble/20150129/msgs/1076603.html