Posted by mattdds on January 25, 2004, at 12:06:21
In reply to Nardil/Maoi questions, posted by jparsell82 on January 22, 2004, at 21:33:51
Hi,
> Is Nardil the only Maoi or Rima that has GABA activity?
The GABA activity comes from the inhibition of of an enzyme called GABA transaminase, which is an enzyme that inactivates GABA. This enzyme being inactivated, GABA concentrations increase. It is not actually phenelzine, but an active metabolite of phenelzine that has this property.
Actually, one of ther other hydrazine derivatives, isocarboxazid (Marplan) also likely has GABAergic activity. Isocarboxazid is very similar to phenezline, and comes from the same family. called the hydrazines. Tranylcipromine (Parnate) does not inhibit GABA transaminase, but for some other reason *does* increase GABA concentrations in the brain.
So, in short. They all do, but perhaps Parnate does it a bit differently.
>>Also, what do you think about 45mg a day of Nardil... or do most people go with 60mg/day for SP? Would 45mg be a sufficient dosage for a 150-160lb person?In the case of Nardil the dose is not really related to weight. It is more dependent on things that are at this time unmeasurable (e.g. liver enzymes that break down the drug, etc.). The process is largely trial and error. 45 mg is a good starting dose, from what I understand. This is the starting dose listed in the PDR.
> Note: I have social anxiety, generalized anxiety, ocd, add and depression.Barring possibly the ADD, these are all indications for which Nardil is purportedly very effective, particularly social anxiety and depression.
I'm currently on 60 mg of Nardil, and starting to see some effects.
Good luck!
Matt
poster:mattdds
thread:303305
URL: http://www.dr-bob.org/babble/20040122/msgs/305318.html