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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 16 of 16. This is the beginning of the thread.
Posted by PeterMartin on July 25, 2019, at 9:49:58
Maybe some random good news for men on Nardil. May 2019 study.
https://www.ncbi.nlm.nih.gov/pubmed/30693539
RESULTS:
We observed that MAOAIs, particularly clorgyline and phenelzine, were effective at decreasing MAOA activity in human prostate cancer cells. MAOAIs significantly decreased growth of LNCaP, C4-2B, and 22Rv1 cells and produced additive growth inhibitory effects when combined with enzalutamide. Clorgyline decreased expression of AR-FL and AR-V7 in 22Rv1 cells and was effective at decreasing growth of an enzalutamide-resistant C4-2B cell line with increased AR-V7 expression.CONCLUSIONS:
MAOAIs decrease growth and proliferation of androgen-sensitive and castration-resistant prostate cancer cells. Clorgyline, in particular, decreases expression of AR-FL and AR-V7 expression and decreases growth of an enzalutamide-resistant cell line. These findings provide preclinical validation of MAOA inhibitors either alone or in combination with antiandrogens for therapeutic intent in patients with advanced forms of prostate cancer
Posted by sigismund on July 25, 2019, at 15:07:24
In reply to Nardil may help prevent/treat prostate cancer(2019, posted by PeterMartin on July 25, 2019, at 9:49:58
Yes, absolutely, pity about the unavailability of clorgyline. Castration resistant cancer cells? Something to look forward to, perhaps for me, although I don't really care enough.
Posted by SLS on July 26, 2019, at 10:22:30
In reply to Re: Nardil may help prevent/treat prostate cancer(2019, posted by sigismund on July 25, 2019, at 15:07:24
> Yes, absolutely, pity about the unavailability of clorgyline. Castration resistant cancer cells? Something to look forward to, perhaps for me, although I don't really care enough.
In the U.S., the NIMH (NIH) abandoned clorgyline for use in humans due to a few incidents of heart attacks.
To date, clorgyline represents the most potent antidepressant in the world.
- Scott
Posted by sigismund on July 26, 2019, at 13:06:39
In reply to Re: Nardil may help prevent/treat prostate cancer(2019, posted by SLS on July 26, 2019, at 10:22:30
I forget exactly what you said about your experience with it.
Complete remission?
Posted by SLS on July 26, 2019, at 19:33:34
In reply to Re: Nardil may help prevent/treat prostate cancer(2019 » SLS, posted by sigismund on July 26, 2019, at 13:06:39
> I forget exactly what you said about your experience with it.
>
> Complete remission?Your memory is excellent, and I am grateful that you should think of me.
I was given clorgyline at a time when I was completely unresponsive to all of the drugs I was trying, including Parnate and Nardil. I responded to clorgyline, but only partially. The improvement was inadequate, and still left me depressed and unemployable. I asked the doctor at the NIH if he would consider adding a TCA to it. He wouldn't do it. I understood why, but felt that I needed to move forward.
It may be that clorgyline is particularly effective because it is irreversible and specific for MAO-A.
- Scott
Posted by Lamdage22 on July 26, 2019, at 22:17:13
In reply to Re: Nardil may help prevent/treat prostate cancer(2019 » sigismund, posted by SLS on July 26, 2019, at 19:33:34
If there only was an MAOI that targets Serotonin only. I always had (pre)psychotic problems even on Moclobemide!
Posted by sigismund on July 27, 2019, at 7:00:22
In reply to Re: Nardil may help prevent/treat prostate cancer(2019, posted by Lamdage22 on July 26, 2019, at 22:17:13
I couldn't tolerate the full dose of moclobemide but the little I took seemed to smarten me up.
It helped with verbal fluency, and not surprisingly made me feel like having a stiff drink.
Posted by ed_uk2010 on July 27, 2019, at 11:19:55
In reply to Re: Nardil may help prevent/treat prostate cancer(2019, posted by sigismund on July 27, 2019, at 7:00:22
> I couldn't tolerate the full dose of moclobemide but the little I took seemed to smarten me up.
>
> It helped with verbal fluency, and not surprisingly made me feel like having a stiff drink.I tried moclobemide years ago... but it was less effective than an SSRI. It totally didn't help at all. I was on 300mg twice a day.
Posted by ed_uk2010 on July 27, 2019, at 11:22:51
In reply to Re: Nardil may help prevent/treat prostate cancer(2019, posted by sigismund on July 25, 2019, at 15:07:24
> Yes, absolutely, pity about the unavailability of clorgyline. Castration resistant cancer cells? Something to look forward to, perhaps for me, although I don't really care enough.
All men get prostate cancer if they live long enough, but it often just sits there doing nothing.
For those unlucky enough to have metastatic prostate cancer, castration is now done reversibly with meds, rather than surgery, but the side effects are the same.... :/ Zoladex injection is a pretty standard 'chemical castration'. It never cures the cancer but it can temporarily shrink the mets enough to relieve pain a lot.
Posted by TH on July 27, 2019, at 16:52:47
In reply to Re: Nardil may help prevent/treat prostate cancer(2019 » sigismund, posted by ed_uk2010 on July 27, 2019, at 11:19:55
> I tried moclobemide years ago... but it was less effective than an SSRI. It totally didn't help at all.
This was my experience also.
Posted by sigismund on July 27, 2019, at 19:46:40
In reply to Re: Nardil may help prevent/treat prostate cancer(2019 » sigismund, posted by ed_uk2010 on July 27, 2019, at 11:22:51
Moclobemide certainly did something, but I did't like it, not enough to continue. This was on half a tablet.
3+3=6 Gleason years ago, which tells us little about the future aggressiveness of the cancer?
Now I have multi parametric MRIs every 2 years after all this time, to begin with it was every year.
I wasn't too keen on the invasiveness of advanced biopsies, although from the others they would now have a better idea of where in the prostate to take the sample.
Posted by sigismund on July 27, 2019, at 19:50:00
In reply to Re: Nardil may help prevent/treat prostate cancer(2019 » ed_uk2010, posted by sigismund on July 27, 2019, at 19:46:40
And maybe they would analyse the biology of the cancer in subsequent biopsies to predict future aggressiveness of the cancer cells? That is histology? Can this be done?
Posted by ed_uk2010 on July 31, 2019, at 6:38:36
In reply to Re: Nardil may help prevent/treat prostate cancer(2019 » ed_uk2010, posted by sigismund on July 27, 2019, at 19:46:40
Hi S,
3+3=6 Gleason is the lowest possible grade of prostate cancer, right? I believe a lot of men just have this and don't know. The regular MRIs sound good, and like something you wouldn't get here. 'Just come back if you have any problems, Sir'.
Posted by Lamdage22 on July 31, 2019, at 20:09:50
In reply to Re: Nardil may help prevent/treat prostate cancer(2019 » sigismund, posted by ed_uk2010 on July 31, 2019, at 6:38:36
I am 30. Do I already need prostate exams? I was riding a bicycle and it really hurt. It was a men saddle.
Posted by rose45 on August 14, 2019, at 14:24:26
In reply to Re: Nardil may help prevent/treat prostate cancer(2019, posted by Lamdage22 on July 31, 2019, at 20:09:50
are you guys still putting your nardil into enteric coated capsules? Just wondering whether that really made a difference or not?
Posted by Lamdage22 on August 16, 2019, at 11:58:40
In reply to Re: Nardil may help prevent/treat prostate cancer(2019, posted by rose45 on August 14, 2019, at 14:24:26
to me it did not
This is the end of the thread.
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