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Nardil may help prevent/treat prostate cancer(2019

Posted by PeterMartin on July 25, 2019, at 9:49:58

Maybe some random good news for men on Nardil. May 2019 study.

https://www.ncbi.nlm.nih.gov/pubmed/30693539

RESULTS:
We observed that MAOAIs, particularly clorgyline and phenelzine, were effective at decreasing MAOA activity in human prostate cancer cells. MAOAIs significantly decreased growth of LNCaP, C4-2B, and 22Rv1 cells and produced additive growth inhibitory effects when combined with enzalutamide. Clorgyline decreased expression of AR-FL and AR-V7 in 22Rv1 cells and was effective at decreasing growth of an enzalutamide-resistant C4-2B cell line with increased AR-V7 expression.

CONCLUSIONS:
MAOAIs decrease growth and proliferation of androgen-sensitive and castration-resistant prostate cancer cells. Clorgyline, in particular, decreases expression of AR-FL and AR-V7 expression and decreases growth of an enzalutamide-resistant cell line. These findings provide preclinical validation of MAOA inhibitors either alone or in combination with antiandrogens for therapeutic intent in patients with advanced forms of prostate cancer


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poster:PeterMartin thread:1105405
URL: http://www.dr-bob.org/babble/20190513/msgs/1105405.html