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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by Cee on May 11, 2013, at 12:17:07
Hello people
Just looking to see if any body has any info on the best dozing times for 90mg of Nardil per day .I heard a rumor that the company who makes the new Nardil is getting pressured to re think it's formulation of the new Nardil and maybe start remaking the old Nardil. I get this from a compounding pharmacist that has a cont with pizer.
Cee
Posted by Tomatheus on May 11, 2013, at 14:43:06
In reply to Nardil best dozing time, posted by Cee on May 11, 2013, at 12:17:07
Hi Cee,
Do you mean "dosing" (and not "dozing") time? I know that when I took Nardil, I took it five times a day when I was on 75 mg and four times a day when I was on 60 mg. I spread out my doses throughout the day when I took Nardil, taking my first dose in the morning, taking my last dose at bedtime, and spreading out the in-between doses evenly. I've heard of some individuals taking all of their Nardil at once, though. I would imagine that spreading out your doses throughout the day like I did might have the potential to minimize some side effects, though I'd also imagine that the extent to which this would occur would vary from one individual to the next. I would check with your doctor before changing the way you dose your Nardil, but I tend to think that some experimentation might be needed to figure out which dosing strategy might work best for you.
T.
Posted by Cee on May 12, 2013, at 2:49:45
In reply to Re: Nardil best dozing time, posted by Tomatheus on May 11, 2013, at 14:43:06
Hello bigT
I guess I should learn to slow down and spell a bit better.it has been along time since I have talked to you as always thanks for the great info.anyways like I was saying I ran into a great pharmacist who said that she would do any thing in her power to find out about the missing compounds in Nardil and also why they changed the formula and also get the original formulation for the old Nardil ,I printed off the post that you did and gave it to her it seemed to help a lot. I am on 90 mg of Nardil 3t times a day and it seems to be working ok for me, I feel that I could still get a litle more out of it ,I did take the old Nardil once and I know that it was a lot more powerful and had a great feel to it. I have experimented with many different things to try and make the new Nardil like the old with out increasing my 90 mg dose.I have taken an ant acid 40minutes before my dose .I have tried enteric capsules without any great succsess. I have taken my Nardil on an empty stomach with any great succsess . But one night I decided to add some of the missing compounds in gelling caps ,honey ,sugar, corn starch, white wheat, talc, alcohol and my divided up Nardil which I also put in gelling caps. I took the compounds first and then my Nardil about 40 min later.wow in the morning I woke up and felt great just like the old Nardil used to feel when I was taking it. I felt euphoric and most happy. This feeling was great and only lasted about three days but this proved to me that it is the missing compounds that are making the new Nardil not as good as the old Putting Nardil into a enteric capsule does not work it is the missing compounds that make the difference.I have a pharmacist working on the missing compounds ,I will take the missing compounds in a separate gelling cap than the Nardil and then swallow them together. I hope that my spelling is ok and I am getting my point across it has nothing to do with the hard coating. The pharmacist told me that any body affected by the formulation change should write there health board or phizer and complain about the change in the old Nardil she said that her contact at phizer said it is the best way to make them go back to the old formulation. She said that it was hard for her to believe that they had changed the formula in the first place. I must give you a little history on myself and my struggle with anxiety and depression ,I find this site very helpful in understanding what people are going thru and how similar we all are in are struggle to feel better. My first anxiety attack happened when I was 18 years old it came out of no where and scarred the he'll out of me ,after a couple of months I started to feel all the symptoms of depression and made my first journey to a pdoc ,well it was the start of a anti depressant trail that lasted many years. Some how when I was about 24 I was put on a med called parnate wow for 18 years I lived my life with no anxiety or depression . Unfortunately after all those years the parnate stopped working and again I began ny death for another anti depressant to help with my bad symptoms.about 2002 after trying many meds my old pdoc decided to give Nardil a try for the first time. At that time my p doc decided to retire so I did not any guidance with the dosage of Nardil . I took 60mg for about 9weeks and wow wow wow, did it ever kick in it was one of the greatest feelings that I have ever experienced. Unfortunately I wasbpretty stupid with my dosing I took to much and it cost me a bout of seratonon syndrum .if it was not for a great doctor I had I would have been dead. After that episode I tried more of the new anti depressants which I did not have any luck with until I came across seroquel. This drug seemed to keep my depression in check for the most part ,but after a couple years it gave me really bad side effects and I had to come off the seroquel. About two weeks after stopping the seroquel I had a the worst deep dark depression of my life I came so close to jumping in the ocean and ending it all. I took my self down to emerg and they admitted me into the pyhyc ward for nine weeks , during that time they had put me back on the new Nardil and after six weeks the gave me thirteen episodes of ect. Well I don't know for sure if the ect helped but the Nardil did kick in about 85 percent. So hear I am trying to put my life back together again like so many of us on this website. I will keep trying to make the new Nardil work better and I will succeed Thank you for listening to an old guy. God bless. Cee
Posted by Tomatheus on May 12, 2013, at 8:39:08
In reply to Re: Nardil best dozing time, posted by Cee on May 12, 2013, at 2:49:45
Hi Cee,
Thank you for sharing your story and for writing about your trials with various medications. It sounds like you respond particularly well to MAOI antidepressants, and I think it's interesting that taking some of the inactive ingredients from the "old" Nardil separately before taking your Nardil seemed to boost the effectiveness of the medication, at least for a brief period of time. It's too bad, though, that you haven't seemed to find a way to get your Nardil to work as well as the old version seemed to work for you over the long haul. I never tried the "old" Nardil myself, and I did have some success with using enteric capsules to prolong the therapeutic benefits of Nardil when I took it, but as you said, the pharmaceutical glaze coating is just one of the differences between the old and new versions of Nardil, and so it doesn't surprise me that re-creating an enteric coating doesn't work for everyone who was affected by the formulation change. I really hope that this rumor that you mentioned in your first post will turn out to be true, so those who were affected by the formulation change and haven't found an effective replacement for Nardil will have a chance to once again take the right version of the medication that worked so well for them. I know that different methods were tried to get "new" Nardil to perform more like "old" Nardil, including creating a liquid Nardil, putting Nardil into enteric capsules, and using a compounded version of Nardil to slow the drug's release, and although all three methods worked for certain individuals, it doesn't seem like any of the methods worked for everybody who was affected by the formulation change. I do wish you luck in your attempts to make "new" Nardil work better, though. I hope that you end up finding a way to get the medication to work at least a little bit better for you.
Take care,
T.
Posted by jono_in_adelaide on May 12, 2013, at 17:41:41
In reply to Nardil best dozing time, posted by Cee on May 11, 2013, at 12:17:07
If you're taking 90mg per day, then 30mg three times a day would make sense, spaced out every 8 hours (30mg morning, afternoon and bedtime more or less)
Posted by Cee on May 13, 2013, at 9:42:23
In reply to Re: Nardil best dozing time, posted by jono_in_adelaide on May 12, 2013, at 17:41:41
Thanks every one
My pharmasisist who really under stands what us Nardil users are going thru says her source at pfyzer says to complain to health Canada or pfzer ,it is the only recourse to get the old Nardil back.
See-man
Posted by Tomatheus on May 13, 2013, at 13:23:25
In reply to Re: Nardil write.fax, email,phone ,pfzer complain, posted by Cee on May 13, 2013, at 9:42:23
Thanks, Cee.
I plan on writing a letter to Pfizer, but I should let you know that many of those who experienced problems with Nardil after the formulation was changed in 2003 already wrote letters to both Pfizer and the U.S. Food and Drug Administration with the ultimate goal of getting Pfizer to restore the "old" Nardil, and obviously nobody succeeded. I was actually part of a group that wrote two letters to the FDA on behalf of those affected by the formulation change. Both letters (particularly the second one, if I'm recalling things correctly) included numerous questions for the FDA, and it's my understanding from what I've read on the Anxiety Community's Nardil forum (when it was still in existence) that at least most of the questions in the letters went unanswered.
The number of people who want to take action to essentially reverse the 2003 Nardil formulation change has dwindled considerably since 2003, 2004, and even 2005 and 2006. So, those of us who would be still be taking action to try to restore the "old" Nardil would make up a small group indeed, which would of course make achieving our goal more difficult. I do think that it's a good idea to continue to make Pfizer and regulatory agencies such as the FDA and Health Canada aware of the fact that there are likely still individuals who would benefit from having the "old" Nardil available. Certainly no change will come about if nobody tells Pfizer and the regulatory agencies that change is wanted. However, making change on this issue will be a great challenge to say the least, and it may require more than taking the same courses of action that have been taken in the past, namely writing to Pfizer, the FDA, and Health Canada.
T.
This is the end of the thread.
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