Psycho-Babble Medication Thread 866242

Shown: posts 1 to 8 of 8. This is the beginning of the thread.

 

Interrressting Concerta ER question and dosing :)

Posted by Jakeo29 on December 2, 2008, at 8:12:41

I was curious on the length of time Concerta lasts in your body. I think its 12 hours. Can it even be longer that with it's advanced delivery method? Concerta is helping. I do not feel the "buzz" that adderall gives or the Euphoric response. But I feel focused, less tired, and not wanted to "give in" with a demanding task. The only reason I seem to "want" to take more is around the 7:00 pm time if I take it around 7:00 in the morning because mentally I am noting that it's wearing off and not sure if I should be more focused in the late evening. I don't crash. A weird thing with stimulants and even Adderall is that I can easily get to sleep even if I take the dose around bedtime (combined with Risperday-to ensure that I do sleep.) One time I took the Concerta at bedtime with the Risperdal and I woke the next morning awake, alert, and ready to go. As ironic and contradictory as it may seem. Is it possible that I bed time dose of Concerta could be benefit my night time sleep with Risperdal and then a daily dose of concerta in the morning, with out the desire to want to take more. It's easy to sway the doctor if he knows that it's helping my sleep disorder by taking it at night and ironically getting a better (how I don't know) night sleep combined with Risperdal? Very inteeeressting :) I am getting a full blood test done on me very soon to make sure my cocktail is doing well. Ironically, physical tests show liver, etc functioning better on all these meds than without meds. Strange hey?

 

Re: Interrressting Concerta ER question and dosing :) » Jakeo29

Posted by Phillipa on December 2, 2008, at 12:24:04

In reply to Interrressting Concerta ER question and dosing :), posted by Jakeo29 on December 2, 2008, at 8:12:41

Welcome to babble hope you get answers to your questions here. Interesting about the liver studies. I'm sorry don't take add's but am interested in all meds. Love Phillipa

 

Re: Interrressting Concerta ER question and dosing :)

Posted by desolationrower on December 2, 2008, at 19:28:35

In reply to Re: Interrressting Concerta ER question and dosing :) » Jakeo29, posted by Phillipa on December 2, 2008, at 12:24:04

I've hear that before, that stimulants help people sleep. Can help with restless limb. There was a study of sleep in people taking them, and after a few months, sleep quality improved for the stimulant takers. Maybe you would be helped by a DA agonist? THey dohn't work for adhd, but often make patients drowsy and help with rls. That would probably seem more conventional to your doc than taking a stiulant. maybe some selegiline or bupropion would be a good idea too.

heres a start

Dopaminergic Control of SleepWake States

Dopamine depletion is involved in the pathophysiology of Parkinson's disease, whereas hyperdopaminergia may play a fundamental role in generating endophenotypes associated with schizophrenia. Sleep disturbances are known to occur in both schizophrenia and Parkinson's disease, suggesting that dopamine plays a role in regulating the sleepwake cycle. Here, we show that novelty-exposed hyperdopaminergic mice enter a novel awake state characterized by spectral patterns of hippocampal local field potentials that resemble electrophysiological activity observed during rapid-eye-movement (REM) sleep. Treatment with haloperidol, a D2 dopamine receptor antagonist, reduces this abnormal intrusion of REM-like activity during wakefulness. Conversely, mice acutely depleted of dopamine enter a different novel awake state characterized by spectral patterns of hippocampal local field potentials that resemble electrophysiological activity observed during slow-wave sleep (SWS). This dopamine-depleted state is marked by an apparent suppression of SWS and a complete suppression of REM sleep. Treatment with D2 (but not D1) dopamine receptor agonists recovers REM sleep in these mice. Altogether, these results indicate that dopamine regulates the generation of sleepwake states. We propose that psychosis and the sleep disturbances experienced by Parkinsonian patients result from dopamine-mediated disturbances of REM sleep.

-d/r

 

Re: Interrressting Concerta ER question and dosing :)

Posted by Jakeo29 on December 2, 2008, at 23:40:02

In reply to Re: Interrressting Concerta ER question and dosing :), posted by desolationrower on December 2, 2008, at 19:28:35

That explains why lose dose Risperdal helps break up excessive REM during night time sleep, thus achieving deep sleep states for treating my Narcolepsy during the day. Xyrem (GHB) is approved to do just this, however there are strict requirements that I do not meet to take that drug. I am going to take my next day dose of Concerta (being about 12:00am) and I took my 1 mg Risperdal. And go to sleep. I should be asleep within 10 minutes. I should wake about 6-7am feeling refreshed. Thats when I take my Strattera, Lamictal, Depakote, Zoloft, and a bit of Provigil (all these are good meds even and seem to work in harmony with my system as I am DX with both Aspergers and Narcolepsy. At 12 pm I will take a second dose of Concerta 36/mg ER. If this further improves daytime sleepiness without desires to take more stimulants because of being tired for no reason except for the Narcolepsy. I will pass this finding to the doctor. I have pretty good experience with the stimulants. Emsam was a good drug, however, being an MAOI, it will not work for a few of the above meds. I do go in for neuropsych testing Jan 7th. I wonder if my struggles are leaning more toward Narcolepsy than AS. Thanks Jake

 

Re: Interrressting Concerta ER question and dosing :) » Jakeo29

Posted by B2chica on December 3, 2008, at 8:35:34

In reply to Interrressting Concerta ER question and dosing :), posted by Jakeo29 on December 2, 2008, at 8:12:41

i've only been on adderall for a short time and i never felt more energy on it so i suppose i wouldnt have any trouble sleeping
However, i remember with ritalin when i'd take it i was able to BETTER take a nap mid day (on weekends), then if i didn't take it. i asked my T about it and she said it helps calm or focus and ruminating thoughts that i get that increase my anxiety which could keep me up.

even if i'd take a dose of ritalin at night i've NEVER had a problem getting to sleep on it.
and i swear it helped.

i think many people react differently, but that's my 2c.
HTH
b2c.

 

Re: Interrressting Concerta ER question and dosing :)

Posted by Jakeo29 on December 3, 2008, at 12:02:55

In reply to Re: Interrressting Concerta ER question and dosing :) » Jakeo29, posted by B2chica on December 3, 2008, at 8:35:34

And to think that I get stigmatized by people with neurotypical functioning who do not understand neuroscience and mental health. They think Ritilan, Adderall, etc is nothing more than smack, crack, speed, and meth. Yes for them it would be. Lets see them try to fall asleep on these. A typical person can stay awke for almost 2 days just on caffeine alone. I would have to literally abuse adderall to just make it 24 hours without sleep. Notice the stigma with these meds come from people who are fine mentally or neuro-psychiatrically? Tom Cruise needs to pick up a book :)

 

Re: Interrressting Concerta ER question and dosing :) » Jakeo29

Posted by 10derHeart on December 3, 2008, at 14:37:40

In reply to Re: Interrressting Concerta ER question and dosing :), posted by Jakeo29 on December 3, 2008, at 12:02:55

I couldn't agree more. It's counter-intuitive I suppose, and there is much ignorance out there in the general public on this point. I have had to explain this to people several times, ("how do you ever calm down/sleep on that "stuff?") and some I am remembering were RNs and MDS. It was not their area of expertise, and if their isn't interest due to a family member of yourself having ADD, well, then, they just don't know....

I too, used to sleep *much* better while taking my MPH doses. If you really educate yourself on AD(H)D then it does make sense, knowing what the ADD-brain does when one tries to sleep! It turns on, revs up, runs through every little thing.....anyway....I always found the stimulant quieted all this and allowed a focus on sleep, if that makes sense. Just like during waking activities, it helped tune out all the chatter and other "channels" so I could do the task at hand.

I take Strattera now, but I remember just what you are saying about Ritalin.

 

Re: Interrressting Concerta ER question and dosing :)

Posted by 10derHeart on December 3, 2008, at 14:40:01

In reply to Re: Interrressting Concerta ER question and dosing :) » Jakeo29, posted by 10derHeart on December 3, 2008, at 14:37:40

Well, your post was about Concerta, of course, not Ritalin. I meant to say I remember and understand what you are saying about *stimulants* and sleep and people not understanding.


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