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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 12 of 12. This is the beginning of the thread.
Posted by BLPBart on May 19, 2002, at 7:56:29
I have been reading up on reboxetine and am convinced that it is the AD for me. I get way too sedated and fat on SSRIs and I have the kind of depression that results in severe lethargy and non-motivation. For what it's worth, I also took the quiz on mindfixers.com and it said my problem was being low in NE and could probably use a little dopamine but it said nothing about needing serotonin. From what I've read about reboxetine it sure sounds like it's the kind of AD for my kind of depression. I was thinking of bringing it up to my pdoc but since it's not approved by the FDA yet and only available mail-order I wasn't sure he would be too hip on it. Do any of you have any experience with it? I'd love to provide my pdoc with testimonials if anyone has any.
Posted by BLPBart on May 22, 2002, at 11:28:10
In reply to Anyone tried reboxetine, posted by BLPBart on May 19, 2002, at 7:56:29
Posted by Ritch on May 22, 2002, at 14:29:29
In reply to Anyone tried reboxetine, posted by BLPBart on May 19, 2002, at 7:56:29
> I have been reading up on reboxetine and am convinced that it is the AD for me. I get way too sedated and fat on SSRIs and I have the kind of depression that results in severe lethargy and non-motivation. For what it's worth, I also took the quiz on mindfixers.com and it said my problem was being low in NE and could probably use a little dopamine but it said nothing about needing serotonin. From what I've read about reboxetine it sure sounds like it's the kind of AD for my kind of depression. I was thinking of bringing it up to my pdoc but since it's not approved by the FDA yet and only available mail-order I wasn't sure he would be too hip on it. Do any of you have any experience with it? I'd love to provide my pdoc with testimonials if anyone has any.
There are people who post and read here that have tried reboxetine-you might need to do a search on it (here) and see what you can dig up. I remember seeing quite a few posts over the past couple of years. I would certainly like to try it-the type of depression I am starting to become immersed in is the apathetic, couch-potato, yawning type of depression, too.
Mitch
Posted by manowar on May 24, 2002, at 13:07:38
In reply to Anyone tried reboxetine, posted by BLPBart on May 19, 2002, at 7:56:29
Hello,
I tried Reboxetine for about 2-3 months and it didn't seem to help me at all. I have the same symptoms of depression that you have. I've also had no luck at all with the SSRIs.There are several TCAs like Desipramine that work on NE receptors. I'm presently on a trial of Nortriptyline, but it's too early to tell whether it's going to help me or not.
Of course Wellbutrin is another drug to consider.
I was diagnosed last year with inattentive ADD along with Cyclothymia, and was started on stimulants last year. They have helped clear some of the fog and it's easier to focus, but they have done nothing at all for my depressive symptoms including low motivation, apathy etc...
I'm very interested in Atomoxetine. If I'm not mistaken, it was originally developed for depression as Tomoxetine, but later as a drug for ADD. It is supposed to be the first non-stimulant that is very effective for people with ADD. It's a very selective NE reuptake blocker. Anyway, that drug was due to be released this spring, but the FDA is dragging their feet in getting it approved.
-Tim
Posted by BLPBart on May 26, 2002, at 13:33:25
In reply to Re: Anyone tried reboxetine » BLPBart, posted by Ritch on May 22, 2002, at 14:29:29
Thanks for your responses. I am currently taking Wellbutrin SR for the depression (it works OK) and dexedrine SR for ADD and it helps with the constant lethargy that I feel. I'm just not sure I want to spend the rest of my life on stimulants...then again, I suppose there are worse things in life.
Posted by fairnymph on May 27, 2002, at 16:45:27
In reply to Re: Anyone tried reboxetine » BLPBart, posted by Ritch on May 22, 2002, at 14:29:29
I have tried reboxetine and I found that it did help my depression substantially.I have also had luck with prozac. Reboxetine had ZERO side effects for me, which was very nice...I really liked it. I was taking 8 mg a day.
Sounds like you are pretty treatment resistant, especially since you didn't respond to the SSRIs. IMO, if you don't respond to either the SSRIs or reboxetine, wellbutrin probably won't do much for you.I would try a totally different line of antidepressants, maybe some stuff like remeron, nefazadone, and trazadone. What kind of side effects (sedation, insomnia, sexual stuff, weight gain/loss) can you stand/not stand?
The other drugs I have tried --Effexor, tianeptine, and Remeron did nothing for my depression/OCD.
Posted by BLPBart on May 27, 2002, at 18:32:13
In reply to Re: Anyone tried reboxetine, posted by fairnymph on May 27, 2002, at 16:45:27
> I have tried reboxetine and I found that it did help my depression substantially.I have also had luck with prozac. Reboxetine had ZERO side effects for me, which was very nice...I really liked it. I was taking 8 mg a day.
>
> Sounds like you are pretty treatment resistant, especially since you didn't respond to the SSRIs. IMO, if you don't respond to either the SSRIs or reboxetine, wellbutrin probably won't do much for you.I would try a totally different line of antidepressants, maybe some stuff like remeron, nefazadone, and trazadone. What kind of side effects (sedation, insomnia, sexual stuff, weight gain/loss) can you stand/not stand?
>
>
> The other drugs I have tried --Effexor, tianeptine, and Remeron did nothing for my depression/OCD.Actually, my depression responded pretty well with the prozac, it was just the weight gain, no libido and extreme lethargy that I couldn't take. My doc added wellbutrin to counteract the prozac effects and it seemed like when we combined the two that instead of getting better, the symptoms got worse. I also started having additional symptoms that were a little scary like muscle pain and joint pain that felt like arthritis. My pdoc then had me drop the prozac and go with wellbutrin alone. We then added the dexedrine later because of the ADD and continued fatigue and lethargy, even on the wellbutrin. I've been trying to do some research on my own, and it just seems to me that this kind of depression I have, which makes just getting out of bed in the morning an olympic feat, appears to respond better to the norepinephrine-type meds than the serotonin selective type. I'm interested to hear that you had good results with it. It sounds like you no longer take it. Did you switch or are you no longer on ADs?
Posted by fairnymph on May 28, 2002, at 2:07:28
In reply to Re: Anyone tried reboxetine, posted by BLPBart on May 27, 2002, at 18:32:13
"Actually, my depression responded pretty well with the prozac, it was just the weight gain, no libido and extreme lethargy that I couldn't take."
This was EXACTLY my problem with prozac! Sounds like you would LOVE reboxetine...I had very slightly weight loss, increased libido, and massively increased energy. From the morning after I took my first dose and onwards, I found that reboxetine left me feeling refreshed in the morning and gave me energy throughout the day. Prior to taking reboxetine I was sleeping 10=12 hours a day from my depression, even though when not depressed, I naturally sleep about 6 hours a day. On the reboxetine, I immediately returned to my natural shorter sleep cycle, and paradoxically was feeling more energetic as I said earlier.
Though I felt more energetic and generally 'motivated' as soon as I started taking the reboxetine, I didn't experience any mood elevation until about 2.5 weeks into treatment. I stopped treatment after about 3.5 weeks, as the drug wasn't doing much for my OCD, or my anxiety (though the motivational aspects of the drug overcame some of my anxiety).
Also, I found that my favorite drug (caffeine, heh) as well as any other CNS stimulants had absolutely ZERO stimulatory effects on me, and rather gave me immense headaches...I could take 5 dexedrine and fall asleep an hour later...and then on the comedown (from dexedrine, etc) I would have SEVERE jaw-clenching, back/joint pain, and a throbbing horrible headache. Thus, though I think reboxetine is a remarkable antidepressant, it absolutely cannot be combined with any type of stimulant, without very noticeable negative effects.
I am still considering going back on the reboxetine, as my depression atm is quite severe...
If you want any more info on rebexetine feel free to drop me a line at fairnymph@ziplip.com
Good luck with your AD trials!
~fairnymph
Posted by BLPBart on May 28, 2002, at 10:22:20
In reply to Re: Anyone tried reboxetine » BLPBart, posted by fairnymph on May 28, 2002, at 2:07:28
> "Actually, my depression responded pretty well with the prozac, it was just the weight gain, no libido and extreme lethargy that I couldn't take."
>
> This was EXACTLY my problem with prozac! Sounds like you would LOVE reboxetine...I had very slightly weight loss, increased libido, and massively increased energy. From the morning after I took my first dose and onwards, I found that reboxetine left me feeling refreshed in the morning and gave me energy throughout the day. Prior to taking reboxetine I was sleeping 10=12 hours a day from my depression, even though when not depressed, I naturally sleep about 6 hours a day. On the reboxetine, I immediately returned to my natural shorter sleep cycle, and paradoxically was feeling more energetic as I said earlier.
>
> Though I felt more energetic and generally 'motivated' as soon as I started taking the reboxetine, I didn't experience any mood elevation until about 2.5 weeks into treatment. I stopped treatment after about 3.5 weeks, as the drug wasn't doing much for my OCD, or my anxiety (though the motivational aspects of the drug overcame some of my anxiety).
>
> Also, I found that my favorite drug (caffeine, heh) as well as any other CNS stimulants had absolutely ZERO stimulatory effects on me, and rather gave me immense headaches...I could take 5 dexedrine and fall asleep an hour later...and then on the comedown (from dexedrine, etc) I would have SEVERE jaw-clenching, back/joint pain, and a throbbing horrible headache. Thus, though I think reboxetine is a remarkable antidepressant, it absolutely cannot be combined with any type of stimulant, without very noticeable negative effects.
>
> I am still considering going back on the reboxetine, as my depression atm is quite severe...
>
> If you want any more info on rebexetine feel free to drop me a line at fairnymph@ziplip.com
>
> Good luck with your AD trials!
>
> ~fairnymphThank you very much for your experience with reboxetine. I don't go back to see my pdoc for a while but I'm certainly going to see what he thinks about it. I'm even wondering, based on the way you described your reaction to it, if I would even need the stimulant any more if I tried it.
I'm very sorry to hear that you're having problems with the depression right now. Clearly everyone on this board can relate and I sure hope that you find a combo that works for you. I've always believed that what goes around, comes around and I believe that a board like this helps us all. You're helping me and hopefully you'll find information that will help you, too. Good luck.
Posted by Leighwit on May 29, 2002, at 16:30:59
In reply to Re: Anyone tried reboxetine, posted by BLPBart on May 26, 2002, at 13:33:25
I took Reboxetine and didn't like it. The side effects, for me, were similar to those of Effexor and neither one alleviated my depression symptoms.
I've done better with Wellbutrin SR, although I'm in the process of augmenting it with mood stabilizers, so it hasn't produced a full response.
FWIW,
Laurie
Posted by zeebop on July 15, 2004, at 9:06:16
In reply to Re: Anyone tried reboxetine » BLPBart, posted by fairnymph on May 28, 2002, at 2:07:28
Hi again,
Just want to know if anyone had this combo?Prozac was great for me(the best SSRI),but later gave me sex death,weight gain,and indifference
Edronax was extremley stimulating and gave me severe depression with the "right" dose(8mg)
-How about having fluoxetine20mg + a small dose(1-2mg)of reboxetine to get away the apathy and sexual dysfunction,and give a boost in energy and concentration? any one?
P.S. I'm afraid to put selegiline with fluoxetine because of drug interaction...selegiline alone (5mg) gives me energy....any thoughts please?
Posted by zeebop on July 15, 2004, at 9:09:34
In reply to Re: Anyone tried reboxetine » BLPBart, posted by fairnymph on May 28, 2002, at 2:07:28
Hi again,
Just want to know if anyone had this combo?Prozac was great for me(the best SSRI),but later gave me sex death,weight gain,and indifference
Edronax was extremley stimulating and gave me severe depression with the "right" dose(8mg)
-How about having fluoxetine20mg + a small dose(1-2mg)of reboxetine to get away the apathy and sexual dysfunction,and give a boost in energy and concentration? any one?
P.S. I'm afraid to put selegiline with fluoxetine because of drug interaction...selegiline alone (5mg) gives me energy....any thoughts please?
This is the end of the thread.
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