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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by Ed on September 20, 2000, at 12:25:28
I am wondering whether anyone who, like me, responded well to Nardil, but had to discontinue it, has responded to anything else? I have not, and I have tried just about everything, including overseas. Just wondering.
Posted by JaneST on September 22, 2000, at 12:45:19
In reply to ? for Nardil responders, posted by Ed on September 20, 2000, at 12:25:28
Ed:
I took Nardil for 5 years and it worked wonderfully for me until about the last 6 months...and then I really hit the pits...I think we call that 'poop-out' here. That was almost 2 years ago and depite trying almost every other type of med, alone and in combinations, I have yet to feel as good or 'normal' as I did on the Nardil.
There are those here who say that once you take a break from it, you can go back and try it again, most of the time achieving the desired effect. I don't know that from personal experience because my pdoc does not want to put me back on it: I would have to have a minimum two-week wash out of the Remeron that I am currently taking and she's afraid I would really hit the pits again...and she's also concerned about Nardil's side-effects...(and I didn't ask her specifics about that)...but Nardil is the closest I have come to feeling like myself...and I think I vaguely remember what THAT is...
Don't know if this helps you, but that's been my experience at least. This is supposed to be one of the topics at my next appointment. Let me know how you do.
Sincerely,
Jane
Posted by anita on September 22, 2000, at 22:27:12
In reply to ? for Nardil responders, posted by Ed on September 20, 2000, at 12:25:28
Hi Ed,
Nardil was the only drug I had a significantly good response to, until the side effects and diminished effectiveness after 3+ years made me stop it. I too have tried almost everything out there, including Parnate. I have atypical depression. What I have found helpful so far:
1. St. John's Wort, 1500mg/day
2. Lamictal, 100mg/day (mood stabilizer and antidepressant)
3. Zoloft, 100mg/dayI think nardil may have worked for me because it increased GABA and dopamine more than most other ADs. Zoloft and SJW increase dopamine as well as serotonin, and lamictal can increase GABA (it's a glutamate antagonist).
I've had a poor response to noradrenaline meds. I think amisulpride is worth a shot, tho it stopped working for me after a few weeks.good luck,
anita> I am wondering whether anyone who, like me, responded well to Nardil, but had to discontinue it, has responded to anything else? I have not, and I have tried just about everything, including overseas. Just wondering.
Posted by Ed on September 25, 2000, at 10:48:05
In reply to Re: ? for Nardil responders, posted by anita on September 22, 2000, at 22:27:12
> Hi Ed,
>
> Nardil was the only drug I had a significantly good response to, until the side effects and diminished effectiveness after 3+ years made me stop it. I too have tried almost everything out there, including Parnate. I have atypical depression. What I have found helpful so far:
> 1. St. John's Wort, 1500mg/day
> 2. Lamictal, 100mg/day (mood stabilizer and antidepressant)
> 3. Zoloft, 100mg/day
>
> I think nardil may have worked for me because it increased GABA and dopamine more than most other ADs. Zoloft and SJW increase dopamine as well as serotonin, and lamictal can increase GABA (it's a glutamate antagonist).
> I've had a poor response to noradrenaline meds. I think amisulpride is worth a shot, tho it stopped working for me after a few weeks.
>
> good luck,
> anita
>
Anita-- do you take all three (the SJW, Lamictal and Zoloft)? What would you say your response is, as a % of the response you had to Nardil?I have tried each of the three meds you listed, one at a time. I had no response to the SJW or the Zoloft, and a modest response to the Lamictal, which response pooped out after a week or two. (I also tried Adrafanil/Amisulpride, and each alone, with negligible response). NE drugs do little for me, and SSRI drugs make me feel anxious, agitated and downright paranoid (as do stimulants like Ritalin, though when I was in college the stimulants were helpful for concentration and focus, with no untoward side effects). Thanks.
Posted by SLS on September 25, 2000, at 14:50:09
In reply to Re: ? for Nardil responders, posted by Ed on September 25, 2000, at 10:48:05
> I have tried each of the three meds you listed, one at a time. I had no response to the SJW or the Zoloft, and a modest response to the Lamictal, which response pooped out after a week or two. (I also tried Adrafanil/Amisulpride, and each alone, with negligible response). NE drugs do little for me, and SSRI drugs make me feel anxious, agitated and downright paranoid (as do stimulants like Ritalin, though when I was in college the stimulants were helpful for concentration and focus, with no untoward side effects). Thanks.
What about Effexor and Wellbutrin? Together, they can make for a good combination. If you are partially responsive to both, I would head in that direction. Although I don't know of anyone who has combined Nardil and Wellbutrin, I would be interested to know what you think. Personally, I have been on Parnate + Wellbutrin. It is a safe combination. Unfortunately, Wellbutrin and me just don't seem to get along.
- Scott
Posted by anita on September 26, 2000, at 22:59:45
In reply to Re: ? for Nardil responders, posted by Ed on September 25, 2000, at 10:48:05
Ed,
Yes, I take all three, but sometimes I don't take as much SJW out of laziness. I think Lamictal inhibits its own metabolism, which means that after a few weeks you have to raise the dose to get the same effect. Have you tried selegiline or Marplan? I'm sorry nothing has worked out for you. I'd say the meds I'm on now have about 80% of the effect I had with Nardil.
anita
> Anita-- do you take all three (the SJW, Lamictal and Zoloft)? What would you say your response is, as a % of the response you had to Nardil?
>
> I have tried each of the three meds you listed, one at a time. I had no response to the SJW or the Zoloft, and a modest response to the Lamictal, which response pooped out after a week or two. (I also tried Adrafanil/Amisulpride, and each alone, with negligible response). NE drugs do little for me, and SSRI drugs make me feel anxious, agitated and downright paranoid (as do stimulants like Ritalin, though when I was in college the stimulants were helpful for concentration and focus, with no untoward side effects). Thanks.
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