Posted by Ed on September 25, 2000, at 10:48:05
In reply to Re: ? for Nardil responders, posted by anita on September 22, 2000, at 22:27:12
> Hi Ed,
>
> Nardil was the only drug I had a significantly good response to, until the side effects and diminished effectiveness after 3+ years made me stop it. I too have tried almost everything out there, including Parnate. I have atypical depression. What I have found helpful so far:
> 1. St. John's Wort, 1500mg/day
> 2. Lamictal, 100mg/day (mood stabilizer and antidepressant)
> 3. Zoloft, 100mg/day
>
> I think nardil may have worked for me because it increased GABA and dopamine more than most other ADs. Zoloft and SJW increase dopamine as well as serotonin, and lamictal can increase GABA (it's a glutamate antagonist).
> I've had a poor response to noradrenaline meds. I think amisulpride is worth a shot, tho it stopped working for me after a few weeks.
>
> good luck,
> anita
>
Anita-- do you take all three (the SJW, Lamictal and Zoloft)? What would you say your response is, as a % of the response you had to Nardil?I have tried each of the three meds you listed, one at a time. I had no response to the SJW or the Zoloft, and a modest response to the Lamictal, which response pooped out after a week or two. (I also tried Adrafanil/Amisulpride, and each alone, with negligible response). NE drugs do little for me, and SSRI drugs make me feel anxious, agitated and downright paranoid (as do stimulants like Ritalin, though when I was in college the stimulants were helpful for concentration and focus, with no untoward side effects). Thanks.
poster:Ed
thread:44963
URL: http://www.dr-bob.org/babble/20000905/msgs/45258.html