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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 9 to 33 of 58. Go back in thread:
Posted by Phillipa on April 26, 2008, at 19:32:28
In reply to Re: A few Cyprenil (liquid selegiline citrate) ?s, posted by bulldog2 on April 26, 2008, at 8:17:52
Didn't know you had been on ENSAM? Phillipa
Posted by bulldog2 on April 26, 2008, at 19:51:51
In reply to Re: A few Cyprenil (liquid selegiline citrate) ?s » bulldog2, posted by Phillipa on April 26, 2008, at 19:32:28
> Didn't know you had been on ENSAM? Phillipa
For a month at the lowest patch dose. Some insomnia and increased energy. No real AD effect but maybe needed to go to a higher dosed patch. Didn't make me jittery so I disagree with your doc that it might be to stimulating for you. Everydone reacts differently.
Posted by Phillipa on April 26, 2008, at 21:02:00
In reply to Re: A few Cyprenil (liquid selegiline citrate) ?s, posted by bulldog2 on April 26, 2008, at 19:51:51
Bulldog but I have anxiety you say you have add or want something to perk up I want to perk down. Love Jan
Posted by Alucard on April 26, 2008, at 21:03:44
In reply to Re: A few Cyprenil (liquid selegiline citrate) ?s, posted by bulldog2 on April 26, 2008, at 19:51:51
I think if you're having problems with too much stimulation, insomnia or jittery effects you could try combining the selegiline with 1500 mg of L-tryptophan daily, which would increase serotonin and melatonin levels to balance with the increased norepinephrine and dopamine from the selegiline. Take 500mg L-tryptophan on an empty stomach with some fruit juice three times a day and see how that works for anti-depressant and pro-healthy-sleep-pattern effects. From what I've experienced, L-trypophan (increased serotonin) leads to a "chill" kind of mood lift so that irritating things like traffic just don't bug you as much, whereas dopamine+norepinephrine boosters give a more active, energetic mood lift, but with less tolerance for irritable situations. Combining both seems well worth a shot for y'all with more serious depression. Actually I think I'll give it a shot myself, and post any good results. Anybody tried this particular combo?
Posted by undopaminergic on April 26, 2008, at 21:23:05
In reply to Re: A few Cyprenil (liquid selegiline citrate) ?s, posted by bulldog2 on April 25, 2008, at 15:00:52
> You would think with the sublinqual it would be easier on a milligram by milligram basis to reach the point at which it would inhibit mao-a also.
>Yes. Note that there is no precise "magic" point where it starts to inhibit MAO-A. Rather, MAO-A inhibition is likely to be a (gradual) function of drug concentration and time. There is almost certainly a measurable - but not clinically significant - effect on MAO-A already at standard doses, especially after chronic treatment, perhaps in the range of 10-20%. Furthermore, the dose-response curve is not linear, but begins to flatten as higher levels of inibition are approached, or in other words, the last few percent of MAO are very resistant to inhibition, whereas the first 80-90% are very easily conquered.
Posted by undopaminergic on April 26, 2008, at 22:23:12
In reply to Re: A few Cyprenil (liquid selegiline citrate) ?s, posted by bulldog2 on April 26, 2008, at 8:17:52
>
> Anyone have any idea how much of the deprenyl is absorbed under the tongue? If there is a high conversion rate you could use the liquid as an AD and get mao-a inhibition. I hated the patch as you only have three sizes and they left big blotches and was just inconvenient. With the drops you can titrate more conviently.
>One study found that 1.25 mg sublingual Zydis selegiline was equivalent to 10 mg of oral (swallowed) selegiline tablets, in terms of plasma selegiline contrentrations, while metabolite levels were much lower for the sublingual form.
Posted by bulldog2 on April 26, 2008, at 23:29:19
In reply to Re: A few Cyprenil (liquid selegiline citrate) ?s, posted by undopaminergic on April 26, 2008, at 22:23:12
> >
> > Anyone have any idea how much of the deprenyl is absorbed under the tongue? If there is a high conversion rate you could use the liquid as an AD and get mao-a inhibition. I hated the patch as you only have three sizes and they left big blotches and was just inconvenient. With the drops you can titrate more conviently.
> >
>
> One study found that 1.25 mg sublingual Zydis selegiline was equivalent to 10 mg of oral (swallowed) selegiline tablets, in terms of plasma selegiline contrentrations, while metabolite levels were much lower for the sublingual form.we know that 10 mg of oral deprenyl by itself is considered safe and is basically an mao-b inhibitor. I haven't seen any studies comparing cyprenil to the oral form. So who knows what the ratio between the two forms is. We know that we have to get into the 40 - 60 range with the tablets to inhibit mao-a enough to be meaningful.I believe the tablets have an absorption rate of about 10 % would like to find the rate for liquid deprenyl.
Posted by Alucard on April 27, 2008, at 1:49:08
In reply to Re: A few Cyprenil (liquid selegiline citrate) ?s, posted by bulldog2 on April 26, 2008, at 23:29:19
1.25mg sublingual citrate = approx. 10mg oral hydrochloride? Wow, no wonder such a difference in effects is reported between the two forms.
Interesting thought: everybody who's done any amount of research on selegiline has come across the rat (and other mammal) studies where selegiline extended potential life span so dramatically. My question is this - what was the method of administration and exact formulation (citrate, hyrochloride, freebase in saline solution, or some other form entirely?) of the drug in those studies? If I had to guess I'd say that injection was the route of administration, and if that's the case then the more direct the route of administration the better (i.e. injection > patch > sublingual > oral). Hmmmmmm.
Posted by bulldog2 on April 27, 2008, at 9:32:40
In reply to Re: A few Cyprenil (liquid selegiline citrate) ?s, posted by Alucard on April 27, 2008, at 1:49:08
> 1.25mg sublingual citrate = approx. 10mg oral hydrochloride? Wow, no wonder such a difference in effects is reported between the two forms.
>
> Interesting thought: everybody who's done any amount of research on selegiline has come across the rat (and other mammal) studies where selegiline extended potential life span so dramatically. My question is this - what was the method of administration and exact formulation (citrate, hyrochloride, freebase in saline solution, or some other form entirely?) of the drug in those studies? If I had to guess I'd say that injection was the route of administration, and if that's the case then the more direct the route of administration the better (i.e. injection > patch > sublingual > oral). Hmmmmmm.The problem with the patch is there are only three sizes so there's not room for titration. Plus I found they fell off last summer when I sweated during exercise. Like to see zelapar used for depression. I imagine it would work like the patch since it bypasses the stomach and liver first pass.
Posted by Amigan on April 28, 2008, at 7:31:56
In reply to A few Cyprenil (liquid selegiline citrate) ?s, posted by Alucard on April 23, 2008, at 21:56:46
I'm not sure of this, but i feel that oral administration works better for me. It improves my mood much better than the sublingual administration which does very little for my mood.
About the effects of Selegiline on NA that i keep reading about: Are there any evidences that Selegiline increases NA at MAO-B selective dose range and not just Dopamine and PEA?
Posted by undopaminergic on April 28, 2008, at 10:12:46
In reply to Re: A few Cyprenil (liquid selegiline citrate) ?s, posted by Amigan on April 28, 2008, at 7:31:56
> I'm not sure of this, but i feel that oral administration works better for me. It improves my mood much better than the sublingual administration which does very little for my mood.
>
> About the effects of Selegiline on NA that i keep reading about: Are there any evidences that Selegiline increases NA at MAO-B selective dose range and not just Dopamine and PEA?
>PEA and the amphetamines dose dependently release dopamine and noradrenaline. Amphetamines also release serotonin, but less potently and at higher doses than for the catecholamines.
Many people find amphetamines to be effective mood boosters, but tolerance and addiction are potential problems.
There is some evidence that selegiline is more noradrenergic than rasagiline, and that is probably due to the amphetamines, but there are very few studies comparing the two MAO-B inhibitors, and it may be interesting to note that they are all co-authored by Dr. Youdim, the "father" of rasagiline.
Posted by undopaminergic on April 28, 2008, at 20:11:50
In reply to Re: A few Cyprenil (liquid selegiline citrate) ?s, posted by Alucard on April 27, 2008, at 1:49:08
> 1.25mg sublingual citrate = approx. 10mg oral hydrochloride?
>No, sublingual hydrochloride.
> Wow, no wonder such a difference in effects is reported between the two forms.
>
> Interesting thought: everybody who's done any amount of research on selegiline has come across the rat (and other mammal) studies where selegiline extended potential life span so dramatically. My question is this - what was the method of administration and exact formulation (citrate, hyrochloride, freebase in saline solution, or some other form entirely?) of the drug in those studies? If I had to guess I'd say that injection was the route of administration, and if that's the case then the more direct the route of administration the better (i.e. injection > patch > sublingual > oral). Hmmmmmm.
>Sublingual beats transdermal (the sublingual tissue is more permeable than regular skin).
Dr. Knoll used subcutaneous injections of 0.25 mg/kg L-deprenyl three times a week in his famous experiment where some of the selegiline-treated rats lived longer than the documented maximum life span of the rat strain in question. The abstract doesn't mention which form was used, but I presume it was the hydrochloride, because it's stable and readily soluble in water, whereas the freebase is reportedly volatile and poorly soluble.
It appears that the EMSAM patches use the freebase, which is a yellow to colourless oily liquid.
From what I've been able to discern, the so-called liquid selegiline citrate products are actually the freebase stabilised with citric acid and possibly other preservatives. In fact, I've been unable to find any proof of the existence of other forms of selegiline than the hydrochloride salt and freebase, although it would almost certainly be possible to produce some.
Some liquid selegiline products are reportedly mere aqueous solutions of the hydrochloride.
What is your liquid selegiline like? Is it an oily yellowish liquid, or does it seem more like water?
Posted by bulldog2 on April 29, 2008, at 8:40:10
In reply to Re: A few Cyprenil (liquid selegiline citrate) ?s, posted by undopaminergic on April 28, 2008, at 20:11:50
> > 1.25mg sublingual citrate = approx. 10mg oral hydrochloride?
> >
>
> No, sublingual hydrochloride.
>
> > Wow, no wonder such a difference in effects is reported between the two forms.
> >
> > Interesting thought: everybody who's done any amount of research on selegiline has come across the rat (and other mammal) studies where selegiline extended potential life span so dramatically. My question is this - what was the method of administration and exact formulation (citrate, hyrochloride, freebase in saline solution, or some other form entirely?) of the drug in those studies? If I had to guess I'd say that injection was the route of administration, and if that's the case then the more direct the route of administration the better (i.e. injection > patch > sublingual > oral). Hmmmmmm.
> >
>
> Sublingual beats transdermal (the sublingual tissue is more permeable than regular skin).
>
> Dr. Knoll used subcutaneous injections of 0.25 mg/kg L-deprenyl three times a week in his famous experiment where some of the selegiline-treated rats lived longer than the documented maximum life span of the rat strain in question. The abstract doesn't mention which form was used, but I presume it was the hydrochloride, because it's stable and readily soluble in water, whereas the freebase is reportedly volatile and poorly soluble.
>
> It appears that the EMSAM patches use the freebase, which is a yellow to colourless oily liquid.
>
> From what I've been able to discern, the so-called liquid selegiline citrate products are actually the freebase stabilised with citric acid and possibly other preservatives. In fact, I've been unable to find any proof of the existence of other forms of selegiline than the hydrochloride salt and freebase, although it would almost certainly be possible to produce some.
>
> Some liquid selegiline products are reportedly mere aqueous solutions of the hydrochloride.
>
> What is your liquid selegiline like? Is it an oily yellowish liquid, or does it seem more like water?I believe the 1.25 to 10 ratio is for zelapar the new sublingual tablet for pd. So we don't know if the liquids are absorbed that well.
On a more disconcerting note Discovery who made the first liquid depreynyl citrate which is now off the market claims that selepryl and ceprenyl are fakes and are just liquid selegiline hcl.
I wrote the company that makes these meds and asked them about that and have not heard from them yet.
Posted by alucard on April 29, 2008, at 16:54:32
In reply to Re: A few Cyprenil (liquid selegiline citrate) ?s, posted by bulldog2 on April 29, 2008, at 8:40:10
> What is your liquid selegiline like? Is it an oily yellowish liquid, or does it seem more like water?
undopaminergic - The Cyprenil I'm taking is a clear liquid the consistency of water that has a slightly bitter citric taste to it, so it's not the freebase.
>On a more disconcerting note: Discovery, who made the first liquid depreynyl citrate which is now off the market claims that selepryl and cyprenil are fakes and are just liquid selegiline hcl.
I wrote the company that makes these meds and asked them about that and have not heard from them yet.bulldog2 & undopaminergic & everybody - I too read Discovery's claim that Cyprenil and Selepryl were actually just liquid selegiline HCl intentionally mislabeled as the citrate, and I read that BEFORE I ordered the Cyprenil. Here's my thoughts on it:
First of all, as Discovery mentions on their website, they never actually made the liquid deprenyl citrate (LDC from now on) themselves, they contracted with a Mexican pharmaceutical company called Cyto-Pharma to make it for them. Apparently Discovery developed the PROCEDURE to make LDC, but then they licensed the use of that procedure to Cyto-Pharma so it could be made cheaply and then imported through Discovery. This is important because one of the so-called "fake" LDCs (Selepryl) is produced by a Mexican pharmaceutical company called...Cyto-Pharma. When Discovery's offices in Florida were raided and they were shut down in 1993, do you think all the chemists at Cyto-Pharma's lab in Mexico suddenly forgot the LDC manufacturing procedure? Definitely not, and on top of that chemists keep very detailed records of procedures. Furthermore, in the Mexican pharmaceutical market matters of licensing, patents, etc. are basically ignored, so Discovery getting shut down was actually just a free pass to Cyto-Pharma to sell their product directly to the American consumers of LDC under their own brand name (Selepryl instead of Discovery) with no competition (until Cyprenil came along of course).
Secondly, Discovery's claim that nobody else in the whole world has figured out how to make selegiline citrate is just plain ridiculous and insultingly unscientific, along with quite a few other claims on their website. I majored in organic chemistry in college and I can tell you this with certainty: practically any freebase that can be stabilized with hydrochloride can also be stabilized with citrate. Or, for that matter, with hydrogen cyanide (not that you'd want to use that particular one for ingestion), or any of a dozen other similar molecules. There are a few exceptions to this, BUT if one chemist can stabilize selegiline freebase with citrate, then so can anybody else with a year or two of organic chemistry training. It's just not that complex. So if Discovery can make selegiline citrate, then so can anybody else.
While we're on the subject of Discovery's claims about LDC, I may as well address this one too: Discovery claims that selegiline citrate is a "different chemical entity" than selegiline hydrochloride. This is technically TRUE, and it definitely matters when discussing subligually-absorbed selegiline. It doesn't matter if you simply swallow the LDC, because your stomach is filled with hydrochloric acid which will convert LDC to LD-Hydrochloride before it is absorbed. BUT if you absorb LDC through the mucus membrane under your tongue and in the rest of your mouth, you bypass that conversion to the hydrochloride form and allow the citrate form to go more or less directly into your bloodstream. Why is this important? Because sometimes stabilizer molecules (citrate, hydrochloride, hydrogen cyanide, etc.) have medically important effects themselves, and/or they interfere with the effect of the drug they are stabilizing. The stabilizer molecules can also aid or hinder absorption and use of the drug they are stabilizing. This can be seen most commonly in vitamins. Calcium citrate, for example, is better absorbed than tri-calcium phosphate, and is thus a better form to take if you must get your calcium from a pill. Both forms are "calcium", but they can technically be called "different chemical entities" because they absorb differently and are processed differently by your body. The same is true for selegiline citrate vs. selegiline hydrochloride, but ONLY when used sublingually or injected.
The Discovery scientists, while they were certainly pioneers of brilliant alternative therapies for many different ailments, appear to have become possessed by the persecuted-savior-complex. I have no doubt that they were intentionally screwed over and discredited by the FDA & Friends, but that doesn't mean that they are 100% correct about everything and beyond reproach. A good portion of their science and information is sound (including the majority of their "conspiracy" theories, in my opinion), but some of it is just a hysterical temper tantrum thrown by a toddler who's been treated unfairly. Like their claim that other people who are making LDC are liars and fakes. It sounds to me like they're just pissed that not only do they no longer have the LDC market cornered but they don't even have a little PIECE of that market any more. However, I have a hard time understanding why they don't just relocate to a foreign country if they really believe everything they write on their website. You'd think if you really believed you had cures for cancer and AIDS and old age, you might try a little harder to get them to the rest of the world? The FDA has no jurisdiction in Mexico or Canada or ANYWHERE except the U.S., and I hear Europe in particular is a lot more friendly to alternative medicine, but maybe I missed something...
Hope that was helpful and not too long or technical! For the record, I'll be ordering a few bottles of Selepryl to try after the Cyprenil runs out in 2 months and I'll post if I notice any subjective differences.
Posted by undopaminergic on April 30, 2008, at 13:53:58
In reply to Re: A few Cyprenil (liquid selegiline citrate) ?s, posted by alucard on April 29, 2008, at 16:54:32
> >On a more disconcerting note: Discovery, who made the first liquid depreynyl citrate which is now off the market claims that selepryl and cyprenil are fakes and are just liquid selegiline hcl.
> I wrote the company that makes these meds and asked them about that and have not heard from them yet.
>
> bulldog2 & undopaminergic & everybody - I too read Discovery's claim that Cyprenil and Selepryl were actually just liquid selegiline HCl intentionally mislabeled as the citrate, and I read that BEFORE I ordered the Cyprenil. Here's my thoughts on it:
>
> First of all, as Discovery mentions on their website, they never actually made the liquid deprenyl citrate (LDC from now on) themselves, they contracted with a Mexican pharmaceutical company called Cyto-Pharma to make it for them. Apparently Discovery developed the PROCEDURE to make LDC, but then they licensed the use of that procedure to Cyto-Pharma so it could be made cheaply and then imported through Discovery.
>I don't think Cyto-Pharma was given the procedure for making selegiline, only for formulating the so-called "Liquid Deprenyl Citrate" (trade mark). At least according to:
http://www.imminst.org/forum/index.php?showtopic=303&st=0&p=2931&#entry2931Quotation of the relevant passage:
"The procedure to only formulate Liquid Deprenyl Citrate was given to Cyto Pharma, but not the procedure for manufacturing deprenyl. The procedure to manufacture deprenyl free base was given to another company in Mexico. The deprenyl free base was then provided to Cyto Pharma to formulate into Liquid Deprenyl Citrate."> > What is your liquid selegiline like? Is it an oily yellowish liquid, or does it seem more like water?
>
> undopaminergic - The Cyprenil I'm taking is a clear liquid the consistency of water that has a slightly bitter citric taste to it, so it's not the freebase.
>So you believe it's an aqueous solution of the citrate salt of selegiline?
Without further data, I would assume it's a solution of the hydrochloride, because no-one has (to my knowledge) ever reported the preparation of a citrate salt of selegiline. Therefore, the characteristics (melting point, solubility, stability, etc.) of such a compound are unknown.
Theoretically, the molecular weight of selegiline citrate would be 379.40. Therefore 2.03 mg of selegiline citrate would correspond to 1 mg of the freebase, or 1.19 mg of the hydrochloride. You would need to take this into account when determining the dosage.
Posted by bulldog2 on April 30, 2008, at 16:00:07
In reply to Re: A few Cyprenil (liquid selegiline citrate) ?s, posted by undopaminergic on April 30, 2008, at 13:53:58
So selepryl or cyprenil are really selegiline hcl?
Posted by undopaminergic on April 30, 2008, at 16:37:22
In reply to Re: A few Cyprenil (liquid selegiline citrate) ?s, posted by bulldog2 on April 30, 2008, at 16:00:07
I think they very well might be. However, I'm just speculating. The truth would be easy to find out in theory, but who's willing to spend the money and effort on sending a sample of these products to a laboratory for analysis?
Posted by bulldog2 on April 30, 2008, at 17:16:36
In reply to Re: A few Cyprenil (liquid selegiline citrate) ?s, posted by undopaminergic on April 30, 2008, at 16:37:22
> I think they very well might be. However, I'm just speculating. The truth would be easy to find out in theory, but who's willing to spend the money and effort on sending a sample of these products to a laboratory for analysis?
I wrote the company that produces these products about my concerns and they have yet to respond.
Posted by alucard on May 1, 2008, at 2:11:12
In reply to Re: A few Cyprenil (liquid selegiline citrate) ?s, posted by bulldog2 on April 30, 2008, at 17:16:36
I agree with you guys that Cyprenil and Selepryl could quite easily be selegiline HCl, especially given the "flexibility" of Mexican pharmaceutical purity and labeling standards. However, as a chemist I know that it just isn't that difficult to make the citrate form if you've already got a lab equipped to make the hydrochloride form. So why lie about it? There's always the possibility that two separate companies ARE just making the hydrochloride salt and lying about it, but I fail to see the motive when it's so easy to make the real thing and stay honest...
Another related point: the main pharmaceutical chemist who testified FOR Discovery in their lawsuits wrote an affidavit stating that his professional opinion was that the superiority of Discovery's product lay in their purification procedures, NOT in the specific ion (citrate vs. hydrochloride) that they stabilized the selegiline with. So who knows? I think at this point it's pretty much subjective opinion about efficacy, regardless of whether it's citrate or hydrochloride...
Which still doesn't answer the most curious question of all: if Discovery REALLY discovered all these great cures and they're completely prevented from making a profit off of them by the FDA, why the hell don't they just distribute the manufacturing instructions as widely as possible? Sketchy stuff...
Posted by undopaminergic on May 2, 2008, at 12:26:23
In reply to Re: A few Cyprenil (liquid selegiline citrate) ?s, posted by alucard on May 1, 2008, at 2:11:12
> I agree with you guys that Cyprenil and Selepryl could quite easily be selegiline HCl, especially given the "flexibility" of Mexican pharmaceutical purity and labeling standards. However, as a chemist I know that it just isn't that difficult to make the citrate form if you've already got a lab equipped to make the hydrochloride form. So why lie about it?
>Perhaps they don't have a lab equipped to synthesise selegiline, or perhaps they don't have the skills? Perhaps they just buy it from bulk chemical suppliers? In that case they will find the hydrochloride to be the most readily available, whereas the freebase is quire rare, and the citrate absolutely unheard of.
Also, since the properties of the citrate salt of selegiline are unknown, we don't know whether it's water soluble or otherwise suitable for bottling and distribution.
Since you're a chemist, have you considered trying to make your own selegiline - citrate or otherwise? Aren't you at least tempted to evaporate the water from some of your Cyprenil and determine the melting point of the residue? And perhaps hydrolyse it with a base and see whether you get the oily free base of selegiline? Maybe you even have some contacts within the industry who could help you with HPLC, GCMS, or other advanced methods of analysis?
Posted by bulldog2 on May 2, 2008, at 14:32:42
In reply to Re: A few Cyprenil (liquid selegiline citrate) ?s, posted by undopaminergic on May 2, 2008, at 12:26:23
Dedi also made some remark about selepryl and cyprenyl not crossing the blood brain barrier. Not sure how they came to that conclusion.
Posted by undopaminergic on May 2, 2008, at 17:49:56
In reply to Re: A few Cyprenil (liquid selegiline citrate) ?s, posted by bulldog2 on May 2, 2008, at 14:32:42
> Dedi also made some remark about selepryl and cyprenyl not crossing the blood brain barrier. Not sure how they came to that conclusion.
>Some of their writings are just ridiculous and nonsensical. There is overwhelming proof that selegiline - whether in its free base or hydrochloride form - is centrally active.
Posted by Amigan on May 3, 2008, at 0:07:03
In reply to Re: A few Cyprenil (liquid selegiline citrate) ?s, posted by alucard on May 1, 2008, at 2:11:12
Why do you care so much if it's citrate or HCL? Does it even matter?
Posted by Alucard on May 3, 2008, at 2:56:34
In reply to Re: A few Cyprenil (liquid selegiline citrate) ?s, posted by Amigan on May 3, 2008, at 0:07:03
>Why do you care so much if it's citrate or HCL? Does it even matter?
It might, and it might not. It all depends on what form was used in the animal experiments that have yielded such positive results. The original creators of the citrate form (DEDI) have been rather intense about citrate being the only truly effective form, but quite a few claims they make are pretty seriously sketchy (e.g. nobody else in the WHOLE WORLD knows how to manufacture the citrate form), so I take them with 20 or 30 grains of salt.
>Perhaps they (Cyto-Pharma) don't have a lab equipped to synthesise selegiline, or perhaps they don't have the skills?
Selegiline freebase is extremely easy to make with cheap, readily available chemicals. If you were really determined to do it you could make it at home with chemicals acquired at a reasonable cost from your local hardware store and Wal-Mart, or dirt cheap from the internet. So any laboratory of any size, ESPECIALLY a pharmaceutical lab, would definitely be equipped and skilled enough to make it. Making it at home is a BAD IDEA, however, because your product would be nowhere near 99.99% pure and those little impurities can have a HUGELY negative effect. Pharmaceutical labs in particular are very careful to purify their products extensively for this very reason (one fatal mistake and chances are you're going out of business from the bad publicity and ensuing lawsuits, and possibly facing prison time).
>Since you're a chemist, have you considered trying to make your own selegiline - citrate or otherwise? Aren't you at least tempted to evaporate the water from some of your Cyprenil and determine the melting point of the residue? And perhaps hydrolyse it with a base and see whether you get the oily free base of selegiline? Maybe you even have some contacts within the industry who could help you with HPLC, GCMS, or other advanced methods of analysis?
VERY tempted, and not just selegiline but a whole host of other interesting compounds I've come across throughout the years. BUT I'm kinda wandering around the world with nothing more than I can carry in a backpack at the moment, and will be for the indefinite future. This year I'm in Hawai'i, hence my ability to check this forum every few days, but it'll be awhile before I settle down enough (if I ever do) to put a functional lab together and play around with the molecular world first-hand again. As for analysis of the Cyprenil, I'm honestly very surprised that nobody has published anything along those lines on the internet yet (at least that I've been able to find), especially given all the hullaballoo about citrate vs. hydrochloride. Of course DEDI claims that Cyprenil and Selepryl are both fake, but where is the proof? An independent analysis or two is easy enough to get done as a favor if you're a pharmaceutical distributor (even an EX-pharmaceutical distributor), which they are, and the report would be easy enough to upload if you've got your own website, which they do. Yet as with many of their space cadet claims, they don't bother with irrelevant fluff like...proof. That, to me, is strong evidence that they're full of sh*t.
As for me personally, I'm enjoying the effects of the selegiline I've got, whatever form it may be (I feel like I'm getting my A-game back more and more every day, and it hasn't even been 2 weeks). I ordered some capsules of Mucuna pruriens bean extract to synergize with it and cost-effectively augment its effects (since the bean extract is much cheaper than the selegiline). I've heard good things about the combo, the Mucuna pruriens has a hefty amount of dopamine precursors in it, quite a few neuroprotective compounds, etc. so it sounds like selegiline's perfect other half to me.
Mahalo kids =)
Posted by undopaminergic on May 3, 2008, at 11:20:59
In reply to Re: A few Cyprenil (liquid selegiline citrate) ?s, posted by Alucard on May 3, 2008, at 2:56:34
>
> As for me personally, I'm enjoying the effects of the selegiline I've got, whatever form it may be (I feel like I'm getting my A-game back more and more every day, and it hasn't even been 2 weeks).
>Cool. I noticed the strongest effect on the first day, but no improvement over time.
> I ordered some capsules of Mucuna pruriens bean extract to synergize with it and cost-effectively augment its effects (since the bean extract is much cheaper than the selegiline). I've heard good things about the combo, the Mucuna pruriens has a hefty amount of dopamine precursors in it, quite a few neuroprotective compounds, etc. so it sounds like selegiline's perfect other half to me.
>I tried that combination too, but it worked very poorly, so I tried L-dopa+benserazide instead of the herb, but that wasn't really any better.
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