Posted by undopaminergic on April 26, 2008, at 21:23:05
In reply to Re: A few Cyprenil (liquid selegiline citrate) ?s, posted by bulldog2 on April 25, 2008, at 15:00:52
> You would think with the sublinqual it would be easier on a milligram by milligram basis to reach the point at which it would inhibit mao-a also.
>Yes. Note that there is no precise "magic" point where it starts to inhibit MAO-A. Rather, MAO-A inhibition is likely to be a (gradual) function of drug concentration and time. There is almost certainly a measurable - but not clinically significant - effect on MAO-A already at standard doses, especially after chronic treatment, perhaps in the range of 10-20%. Furthermore, the dose-response curve is not linear, but begins to flatten as higher levels of inibition are approached, or in other words, the last few percent of MAO are very resistant to inhibition, whereas the first 80-90% are very easily conquered.
poster:undopaminergic
thread:825078
URL: http://www.dr-bob.org/babble/20080420/msgs/825694.html