Posted by undopaminergic on April 28, 2008, at 10:12:46
In reply to Re: A few Cyprenil (liquid selegiline citrate) ?s, posted by Amigan on April 28, 2008, at 7:31:56
> I'm not sure of this, but i feel that oral administration works better for me. It improves my mood much better than the sublingual administration which does very little for my mood.
>
> About the effects of Selegiline on NA that i keep reading about: Are there any evidences that Selegiline increases NA at MAO-B selective dose range and not just Dopamine and PEA?
>PEA and the amphetamines dose dependently release dopamine and noradrenaline. Amphetamines also release serotonin, but less potently and at higher doses than for the catecholamines.
Many people find amphetamines to be effective mood boosters, but tolerance and addiction are potential problems.
There is some evidence that selegiline is more noradrenergic than rasagiline, and that is probably due to the amphetamines, but there are very few studies comparing the two MAO-B inhibitors, and it may be interesting to note that they are all co-authored by Dr. Youdim, the "father" of rasagiline.
poster:undopaminergic
thread:825078
URL: http://www.dr-bob.org/babble/20080420/msgs/826033.html