Posted by Dopamine123 on February 23, 2008, at 14:06:54
In reply to Re: Salvia and kappa-opioids. » Dopamine123, posted by ShawnThomas on February 22, 2008, at 11:55:52
"Kappa receptors may be ugly in your opinion"
That wasn't my opinion. It was the guy from biopsychiatry.com (David Pearce I think). Sorry if I gave you the impression that it was my opinion.
"only affects the peripheral nervous system."
By that I assume it doesn't affect the brain. A kappa agonist targeted to the brain could potentially cause hallucinations and dysphoria. So they are really two different types of drugs. Salvia gets to the brain, while the peripheral kappa agonist drugs do not.peripheral kappa receptors
http://www.caratherapeutics.com/terminology.php
"As a way to avoid these undesirable CNS effects, there has been an effort to develop opioids which selectively activate (agonist) peripheral opioid receptors such as kappa receptors, present on sensory nerves, outside the central nervous system."
poster:Dopamine123
thread:808350
URL: http://www.dr-bob.org/babble/neuro/20080204/msgs/814269.html