Posted by ShawnThomas on January 23, 2008, at 19:01:02
In reply to Salvia and kappa-opioids., posted by JahL on January 22, 2008, at 14:51:12
The active component of Salvia divinorum, Salvinorin A, is a selective kappa1 opioid receptor agonist
(Ansonoff et al., 2006; http://pubmed.gov/16672569). I'm not sure how this could have any personal implications for you.Although some pain-relieving substances may act at kappa opioid receptors, substances marketed as drugs are not likely to affect kappa1 opioid receptors that are involved in the perceptual distortions and dysphoria associated with Salvia divinorum.
The key mechanism of action shared by most opioid analgesics is mu opioid receptor agonism (i.e., activation).
Shawn
poster:ShawnThomas
thread:808350
URL: http://www.dr-bob.org/babble/neuro/20080114/msgs/808612.html