Posted by ShawnThomas on February 22, 2008, at 11:55:52
In reply to Re: Salvia and kappa-opioids., posted by Dopamine123 on February 21, 2008, at 12:16:13
Kappa receptors may be ugly in your opinion, but they are also a very important therapeutic target. Some kappa opioid receptor agonists that probably do not affect kappa1 receptors are effective analgesics; however, they are not associated with dysphoria. All of the FDA approved kappa agonists also affect mu opioid receptors.
CR665 is a selective kappa opioid receptor agonist that only affects the peripheral nervous system. The drug is beginning phase II clinical trials in the US (http://www.caratherapeutics.com/pipeline-business-strategy.php).
Cara Therapeutics claims that, "Therapeutic indications for peripherally-restricted kappa agonists include, but are not restricted to, post-operative pain and ileus associated with abdominal surgery, pancreatitis pain, dysmenorrhea, labor pain, and irritable bowel syndrome. In addition to their utility as analgesics, kappa agonists have been recognized to possess unique anti-inflammatory actions which may be useful in the treatment of diseases such as rheumatoid arthritis."Shawn
poster:ShawnThomas
thread:808350
URL: http://www.dr-bob.org/babble/neuro/20080204/msgs/814102.html